Journal of Psychiatric Practice Vol. 21, No. 1 January 2015 3 In Section III, Emerging Measures and Models, DSM-5 presents an Alternative Model of Personality Disorders, which is an empirically based model of personality pathology measured with the Level of Personality Functioning Scale (LPFS) and the Personality Inventory for DSM-5 (PID-5). These novel instruments assess level of personality impairment and pathological traits. Objective. A number of studies have supported the psychometric qualities of the LPFS and the PID-5, but the utility of these instruments in clinical assessment and treatment has not been extensively evaluated. The goal of this study was to evaluate the clinical utility of this alternative model of personality disorders. Method. We administered the LPFS and the PID-5 to psychi- atric outpatients diagnosed with personality disorders and other nonpsychotic disorders. The personality profiles of six characteristic patients were inspected (involving a comparison of presenting problems, history, and diagnoses) and used to formulate treatment considerations. We also considered 6 specific personality disor- der types that could be derived from the profiles as defined in the DSM-5 Section III criteria. Results. Using the LPFS and PID-5, we were able to characterize the 6 cases in a meaningful and useful manner with regard to understanding and treatment of the individual patient and to match the cases with 6 relevant personality dis- order types. Implications for ease of use, com- munication, and psychotherapy are discussed. Conclusion. Our evaluation generally supported the utility for clinical purposes of the Alternative Model for Personality Disorders in Section III of the DSM-5, although it also identi- fied some areas for refinement. (Journal of Psychiatric Practice 2015;21:3–25) KEY WORDS: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), personality traits, personality functioning, personality disorders, clinical utility, five-factor model, diagnostics, Levels of Personality Functioning Scale (LPFS), Personality Inventory for DSM-5 (PID-5), therapy A novel approach to personality pathology is includ- ed in Section III, Emerging Measures and Models, of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as a dimensional alternative to the categorical model of personality disorders (PDs) that was retained in Section II of the DSM-5. 1 This alternative model is operationalized with the Level of Personality Functioning Scale (LPFS) 2 and the Personality Inventory for DSM-5 (PID-5). 3 Further investigations of this emerging model will likely result in a major revised approach to PDs in a future version of the DSM and possibly also in ICD-11, which will influence the work of many mental health professionals. As we will review, the psychometric features of the LPFS and the PID-5 have been evaluated with promising results. Such quantitative evaluations are vital to responsible and good clinical use, but we also need to examine the actual clinical utility and usability of this alternative DSM-5 model. One comprehensive survey found that mental health clinicians general- ly judged the DSM-5 Alternative PD Model as more useful than the DSM-IV-TR Axis II model that was retained in DSM-5. 4 In this article, we evaluate clinical utility based on the rationale that clinical instruments should inter- weave meaningfully with clinicians’ experiences, using case vignettes from real world practice. 5,6 First, we review features of the LPFS and the PID-5, including clinical application, scoring, interpreta- tion, and current empirical status. Next, we inspect 6 LPFS and PID-5 profiles of mental health patients, accompanied by their presenting problems, history, and Axis I and II diagnoses according to the DSM-IV- BO BACH, MSc KRISTIAN MARKON, PhD ERIK SIMONSEN, MD ROBERT F. KRUEGER, PhD BACH: Slagelse Psychiatric Clinic, Region Zealand, Denmark; MARKON: University of Iowa, Iowa City; SIMONSEN: Psychiatric Research Unit, Region Zealand, Denmark; KRUEGER: University of Minnesota, Minneapolis. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Please send correspondence to: Bo Bach, Psykiatrien Vest, Inge- mannsvej 18, 4200 Slagelse, Denmark. bobachsayad@gmail.com The authors declare no conflicts of interest. DOI:10.1097/01.pra.0000460618.02805.ef Clinical Utility of the DSM-5 Alternative Model of Personality Disorders: Six Cases from Practice Copyright © Wolters฀Kluwer฀Health,฀Inc.฀ Unauthorized reproduction of this article is prohibited.