_____________________________________________________________________________________________________ *Corresponding author: E-mail: aby_ige@yahoo.com; British Microbiology Research Journal 10(1): 1-7, 2015, Article no.BMRJ.19261 ISSN: 2231-0886 SCIENCEDOMAIN international www.sciencedomain.org Antidermatophytic Activities of Musa sapientum Methanol Leaf Extract in-vitro A. O. Ige 1* and O. O. Mebude 2 1 Department of Physiology, University of Ibadan, Oyo State, Nigeria. 2 Department of Pharmaceutical Microbiology, University of Ibadan, Oyo State, Nigeria. Authors’ contributions This work was carried out in collaboration between both authors. Author AOI designed the study, performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript and managed literature searches. Authors AOI and OOM managed the analyses of the study and literature searches. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/BMRJ/2015/19261 Editor(s): (1) Alok K Upadhyay, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. (2) Eggehard Holler, Cedars-Sinai Medical Center, Department of Neurosurgery, Los Angeles, USA and University of Regensburg, Germany. Reviewers: (1) Anonymous, Ziauddin University, Pakistan. (2) Anonymous, Mevki Military Hospital, Turkey. Complete Peer review History: http://sciencedomain.org/review-history/10587 Received 31 st May 2015 Accepted 30 th July 2015 Published 16 th August 2015 ABSTRACT Aim: The in vitro antidermatophytic activity of methanol leaf extract of Musa sapientum (MSL) against Microsporum canis, Trichophyton tonsurans and Trichophyton rubrum was investigated. Methodology: The methanol leaf extract M. sapientum was obtained by cold extraction. The antifungal activity of the extract was assayed using agar well diffusion techniques. The time-kill antibacterial kinetics of the extract was assessed against one strain of M. canis and two strains of T. tonsurans by plate count technique. Results: The extract had minimum fungicidal concentration (MFC) and minimum inhibitory concentration (MIC) values ranging from 0.0625 mg/ml to 0.5 mg/ml. The least MIC and MFC value was 0.0625 mg/ml against M. canis while T. tonsurans showed the highest MIC and MFC value of 0.5 mg/ml. The extract had no inhibitory or fungicidal effect against T. rubrum. Time-kill kinetic study indicated that the extract exhibited bacteriostatic and bacteriocidal effects against Microsporum canis and Trichophyton tonsurans. Conclusion: The results obtained suggest that the methanol leaf extract of Musa sapientum possesses antidermatophytic properties. Original Research Article