Clinical Pharmacology Division Photo Division Data Summary Research and Training Details Number of Faculty 3 Number of Joint Appointment Faculty 5 Number of Research Fellows 2 Number of Research Students 2 Number of Support Personnel 4 Direct Annual Grant Support $392,294 Direct Annual Industry Support $197,859 Peer Reviewed Publications 12 Significant Publications Prausa SE, Fukuda T, Maseck D, Curtsinger KL, Liu C, Zhang K, Nick TG, Sherbotie JR, Ellis EN, Goebel J, Vinks AA. (2009). UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clin Pharmacol Ther 85, 495-500. Leukopenia and diarrhea are the predominant adverse events associated with mycophenolate mofetil (MMF, CellCept)), leading to dose reduction or discontinuation in children. Polymorphisms of the drug's main metabolizing enzyme, uridine diphosphate-glucuronosyl transferase (UGT), confer alteration in drug exposure. We studied the incidence of these polymorphisms in pediatric kidney transplant recipients experiencing MMF-associated leukopenia