20 Facilitating learning objects reusability in different accessibility settings Pythagoras Karampiperis Advanced e-Services for the Knowledge Society Research Unit, I.T.I, C.E.R.T.H., Greece Demetrios G. Sampson Department of Technology Education and Digital Systems, University of Piraeus, Greece During the last years, accessibility has been recognised as a key design considera- tion for web-based educational systems. However, in real life, each e-learning ser- vices provider uses its own training approach (either driven by theory or driven by the years of practical experience) to design e-learning programmes and uses its own e-learning environment (typically, commercial or open-source Learning Management Systems) to deliver e-learning courses. As a result, the end users (both learners and their tutors) of this particular e-learning services provider can- not easily access other resources available on the web and, moreover, they are en- tirely dependent from the specific e-learning environment in use. This is a recog- nised drawback to the wide spread take-up of e-learning in several contexts of use, including lifelong learning and vocational training. It becomes an even more sig- nificant problem for the application of e-training in Learners with Special Abili- ties. The reason for this is that quality e-learning resources and courses are par- ticularly expensive to develop. Therefore, it is important to be able to built generic e-learning systems that would allow the reuse of existing learning resources in dif- ferent accessibility settings. Towards this end, in this book chapter we present a methodology for defining an accessibility application profile that captures the ac- cessibility properties of learning objects in a commonly identified format. This in- formation is critical in order to be able to match learning content with learner ac- cessibility preferences, as well as, to allow the use of generic hypermedia and multimedia based educational content which is not originally developed for a par- ticular group.