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Brief Communication
Acta Haematol 2008;120:104–107
DOI: 10.1159/000166864
Twice-Weekly High-Dose rHuEpo for the
Treatment of Anemia in Patients with
Low-Risk Myelodysplastic Syndromes
R. Latagliata
a
E.N. Oliva
b
P. Volpicelli
a
I. Carmosino
a
M. Breccia
a
I. Vincelli
b
C. Alati
b
L. Napoleone
a
F. Vozella
a
F. Nobile
b
G. Alimena
a
a
Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, and
b
Department of Hematology, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy
sponse rates exceeding 30–35% with standard rHuEpo
doses (10,000 IU 3 times weekly or 40,000 IU once a
week). These findings were confirmed by Ross et al. [10]
in a meta-analysis considering 150 studies.
The addition of granulocyte colony-stimulating factor
to standard rHuEpo doses has slightly increased the rate
of erythroid response, but this association is expensive
and no positive effect on quality of life has been estab-
lished in a recent randomized study [11]. In order to im-
prove these clinical results, an Italian cooperative group
explored the efficacy of higher rHuEpo doses and showed
a response rate of 150%, with improvement in quality of
life in responders. However, no correlation between re-
sponse to rHuEpo and biological characteristics could be
found due to the lack of data regarding cytogenetics and
serum Epo levels [12].
We performed this prospective non-randomized phase
II study to confirm the efficacy of high-dose rHuEpo and
to evaluate the presence of clinical and biological charac-
teristics affecting quality of life and treatment outcome.
Previously untreated MDS patients from two hemato-
logical departments were considered eligible for this
study in the presence of the following characteristics:
low-risk de novo MDS, defined as low and Int-1 risk
group according to the IPSS prognostic score [3] or mar-
row blasts !10% if a karyotypic analysis failed or was not
Myelodysplastic syndromes (MDS) are a heteroge-
neous group of hemopoietic disorders with peripheral
cytopenia due to ineffective hemopoiesis and a variable
rate of transformation to overt acute myelogenous leuke-
mia [1, 2]. However, patients with low-risk MDS (marrow
blasts !10% or low and intermediate-1, Int-1, risk groups
according to the International Prognostic Scoring Sys-
tem, IPSS) have a relatively longer survival with a lower
rate of leukemic transformation [3]; anemia is the main
cause of symptoms referred by low-risk MDS patients,
with a frequent functional impairment that leads to di-
minished quality of life and survival [4, 5]. As a matter of
fact, anemia occurs in up to 90% of patients at some point
during the course of their disease, with 180% of patients
requiring red blood cell (RBC) transfusion; moreover,
transfusion requirement has recently been reported as a
bad prognostic factor affecting overall survival in each
WHO entity and it has been incorporated in a new WHO-
based scoring system [6].
To manage anemia in these patients, human recombi-
nant erythropoietin (rHuEpo) seemed to be a good op-
tion and has been tested for 120 years. In a previous dou-
ble-blind controlled study, rHuEpo was shown to be sig-
nificantly superior to placebo in low-risk MDS patients,
with an overall response rate of 36.8% [7]. However, this
and many other trials [7–9] were unable to achieve re-
Received: April 29, 2008
Accepted after revision: August 5, 2008
Published online: October 31, 2008
Roberto Latagliata, MD
Department of Cellular Biotechnology and Hematology University La Sapienza
Via Benevento 6
IT–00161 Rome (Italy)
Tel. +39 06 857 951, Fax +39 06 4424 1984, E-Mail rob.lati@libero.it
© 2008 S. Karger AG, Basel
0001–5792/08/1202–0104$24.50/0
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