1 Hsp90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Atul D. Joshi 1 , Christiana Dimitropoulou 2 , Gagan Thangjam 1 , Connie Snead 1 , Sara Feldman 1 , Nektarios Barabutis 1 , David Fulton 1,3 , Yali Hou 1 , Sanjiv Kumar 1,4 , Vijay Patel 5 , Boris Gorshkov 1,2 , Alexander D. Verin 1,2 , Stephen M. Black 1,4 , and John D. Catravas 1,3,* . 1 Vascular Biology Center 2 Section of Pulmonary and critical care, Department of Medicine 3 Department of Pharmacology and Toxicology 4 Department of Obstetrics and Gynecology 5 Department of Cardiothoracic Surgery Georgia Regents University, Augusta, GA 30912-2500 Running Head: Hsp90-Rho in endothelial hyper-permeability * Corresponding author: Dr. John D. Catravas Vascular Biology Center Georgia Regents University Augusta, GA 30912-2500 Phone – 706-721-6339 Email: jcatrava@gru.edu Funding – This work was supported by NIH grants HL101902, HL066993 and HL093460.