* Corresponding author. Tel.: 09960337398; +91 2525 256486 E-mail address: deepakbharti007@gmail.com Peer review under responsibility of board members IJIIT IJIIT/ – see front matter ©2012editor.ijiit.. Hosting by AGSI Publications. All rights reserved. http://ijiit.net ASSOCIATION OF GLOBAL SCIENCE INNOVATIONS (AGSI) (1999) Vol. IV Iss 4 Available online at www.ijiit.net (A Peer Review E-3 Journal of Science Innovation Technology) Journal homepage: http://www.ijiit.net/ Review Paper Diabetes with Hypertension: Etiology, Pathogenesis and Management Deepak Bharati* 1 , Savita Tauro 1 , Swati Rawat 2 , Pankaj Sharma 3 , B. Shrivastav 3 1 St. John Institute of Pharmacy and Research, Palghar, Thane, Maharashtra- 401404, India 2 S.N.D. College of Pharmacy, Yeola, India. 3 Jaipur National University, Jaipur, India. A R T I C L E I N F O Article history: Received 15 July 2015 Received in revised form 02 August 15 Accepted 08 August 2015 Keywords: Diabetes Hypertension Cardiovascular diseases A B S T R A C T There has been an increase in the predominance of diabetes mellitus over the past 40 years worldwide. The worldwide occurrence of diabetes in 2000 was approximately 2.8% and is estimated to grow to 4.4% by 2030. This data interprets a projected rise of diabetes from 171 million in 2000 to well over 350 million in 2030. The presence of hypertension in diabetic patients substantially increases the risks of coronary heart disease, stroke, nephropathy and retinopathy. Indeed, when hypertension coexists with diabetes, the risk of CVD is increased by 75%, which further contributes to the overall morbidity and mortality of an already high risk population. Patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality, and are disproportionately affected by cardiovascular disease. Most of this excess risk is associated with high prevalence of well-established risk factors such as hypertension, dyslipidaemia and obesity in these patients. Hypertension plays a major role in the development and progression of microvascular and macrovascular disease in people with diabetes. Lifestyle Modifications and pharmacotherapy are the choice for the Management of Hypertension in Patients with Diabetes. © 2012 Editor-IJIIT. Hosting by AGSI Publications. All rights reserved. How to cite this article: Deepak Bharati, Savita Tauro, Swati Rawat, Pankaj Sharma and B. Shrivastav (2015). Diabetes with Hypertension: Etiology, Pathogenesis and Management, International Journal of integrative Sciences, Innovation and Technology (IJIIT), 4(4), 7 - 14. 1. Introduction There has been an increase in the predominance of diabetes mellitus over the past 40 years worldwide. The worldwide occurrence of diabetes in 2000 was approximately 2.8% and is estimated to grow to 4.4% by 2030. This data interprets a projected rise of diabetes from 171 million in 2000 to well over 350 million in 2030. 1 The epidemic of diabetes will continue to rise as there is growing prevalence of obesity in children, which predisposes to diabetes. 2 There is significant evidence for an increased prevalence of hypertension in diabetic persons. 3 In a large prospective cohort study that included 12,550 adults, the development of type 2 diabetes was almost 2.5 times as likely in persons with hypertension than in their normotensive people. 4,5 Similarly, evidence points to increased prevalence of hypertension in diabetic persons. Moreover, each pathophysiological disease conditionworks to aggravate the other. Both hypertension and diabetes predisposes to the development of cardiovascular disease (CVD) and renal disease. 3,5 Subjects with diabetes is at about 60% increased risk of