1 Science and Engineering Ethics ISSN 1353-3452 Sci Eng Ethics DOI 10.1007/s11948-014-9587-z An Ethical Issue Scale for Community Pharmacy Setting (EISP): Development and Validation ORIGINAL PAPER Tatjana Crnjanski•Dusanka Krajnovic•Ivana Tadic•Svetlana Stojkov•Mirko Savic email: dusica.krajnovic@pharmacy.bg.ac.rs ABSTRACT Many problems that arise when providing pharmacy services may contain some ethical components and the aims of this study were to develop and validate a scale that could assess difficulties of ethical issues, as well as the frequency of those occurrences in everyday practice of community pharmacists. Development and validation of the scale was conducted in three phases: (i) Generating items for the initial survey instrument after qualitative analysis; (ii) Defining the design and format of the instrument; (iii) Validation of the instrument. The constructed Ethical Issue scale for community pharmacy setting (EISP) has 2 parts containing the same 16 items for assessing the difficulty and frequency thereof. The results of the 171 completely filled out scales were analyzed (response rate 74.89%). The Cronbach’s α value of the part of the instrument that examines difficulties of the ethical situations was 0.83 and for the part of the instrument that examined frequency of the ethical situations was 0.84. Test-retest reliability for both parts of the instrument was satisfactory with all Interclass correlation coefficient (ICC) values above 0.6, (for the part that examines severity ICC = 0.809, for the part that examines frequency ICC = 0.929). The 16-item scale, as a self assessment tool, demonstrated a high degree of content,