IAJPS 2015, 2 (10), 1437-1440 Asif Husain et al ISSN 2349-7750 www.iajps.com Page 1437 CODEN (USA): IAJPBB ISSN: 2349-7750 INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES Available online at: http://www.iajps.com Research Article EVALUATION OF ANTHELMINTIC ACTIVITY OF DI/TRISUBSTIUTED 3-ARYLIDENE-5-(BIPHENYL-4-YL)- 2(3H)-FURANONES Asif Husain 1 *, Mohammad Maaz 2 , Aftab Ahmad 3 , Shah Alam Khan 4 1 Dept of Pharmaceutical Chemistry, Jamia Hamdard (Hamdard University), New Delhi- 110062, India 2 Faculty of Medicine (Unani), Jamia Hamdard (Hamdard University), New Delhi-110062, India 3 Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah-21589, KSA 3 Dept of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Sultanate of Oman Abstract: We describe herein the in vitro anthelmintic activity of di/trisubstituted 3-arylidene-5-(biphenyl-4-yl)-2(3H)- furanones against two species of earthworms i.e. Pheretima posthuma and Perionyx excavatus. The anthelmintic activity was determined by noting the mean paralyzing and death times of the worms due to furanone derivatives at a concentration of 2mg/mL. All the tested compounds displayed moderate to good anthelmintic activity but compounds 1 and 5 were found to be the most potent against Perionyx excavatus and Pheretima posthuma, respectively. These exhibited significant anthelmintic activities against both types of worms and the results were comparable to reference drug albendazole. Keywords: Furnaone, Pheretima posthuma, Perionyx excavatus, Anthelmintic. *Corresponding author: Asif Husain Sr. Asstt. Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi-110 062, India. Phone: +91-11-26059681, 26059688, ext. 5647, Mobile- +91-989-1116086 Fax- +91-11-26059663 Email: drasifhusain@yahoo.com, ahusain@jamiahamdard.ac.in Please cite this article in press as Asif Husain et al , Evaluation of Anthelmintic Activity of Di/Trisubstiuted 3-Arylidene-5-(Biphenyl-4-Yl)-2(3H)-Furanones, Indo Am. J. Pharm. Sci, 2015;2(10). QR code