For Peer Review                               !" #$  %!"& ! ’ (’ ( " )  (’ %’*+, -./ (0 1 2&, 34  ( %5, / %’$6 75 8, "   &  & 0&, %/ (+ 1 2&, 34  ( 6, 7/ (+ 1 2&, 34  ( 9:’&, -/ (+ 1 2&, 34  ( European Journal of Clinical Pharmacology peer-00599459, version 1 - 10 Jun 2011 Author manuscript, published in "European Journal of Clinical Pharmacology 66, 9 (2010) 903-910" DOI : 10.1007/s00228-010-0849-7