The Influence of Nanotopographical Structures on Osteoblast Adhesion Formation and the Functional Response of Mesenchymal Stem Cell Populations Manus Jonathan Paul Biggs For the degree of PhD at the University of Glasgow, UK November 2008 AO Research Institute, Clavadelerstrasse CH 7270 Davos Switzerland Centre for Cell Engineering, Division of Infection and Immunity, University of Glasgow, G12 8QQ United Kingdom