1 1 FORUM ORIGINAL RESEARCH COMMUNICATION Forum Editor: Andreas Daiber Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species – studies in white blood cells and in animal models Swenja Kröller-Schön a *, Sebastian Steven a *, Sabine Kossmann a,b , Alexander Scholz a , Steffen Daub a , Matthias Oelze a , Ning Xia c , Michael Hausding a , Yuliya Mikhed a , Elena Zinßius a , Michael Mader a , Paul Stamm a , Nicolai Treiber d , Karin Scharffetter-Kochanek d , Huige Li c , Eberhard Schulz a , Philip Wenzel a,b , Thomas Münzel a , and Andreas Daiber a¶ From the a 2nd Medical Clinic, Department of Cardiology, b Center of Thrombosis and Hemostasis, c Department of Pharmacology, Medical Center of the Johannes Gutenberg University, Mainz, Germany; d Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany. Running title: Mitochondrial ROS activate NADPH oxidase * S.K.-S. and S.S. contributed equally to this study and should therefore both be considered as first author ¶ Address correspondence to: Prof. Dr. Andreas Daiber, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, II. Medizinische Klinik, Molekulare Kardiologie, Langenbeckstr. 1, 55131 Mainz, Germany, E- mail: andreas.daiber@bioredox.com Page 1 of 54 Antioxidants & Redox Signaling Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species – studies in white blood cells and in animal models (doi: 10.1089/ars.2012.4953) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.