Indian J Psychiatry 56 (Supplement), January 2014 S63 Insight in obsessive compulsive disorder: Concordance amongst various measurements Abhishek Ghosh, Sandeep Grover, Siddharth Sarkar, Natasha Kate, Ajit Avasthi, Savita Malhotra Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India Aims and Objectives: The objective of this study was to compare the concordance amongst three different measurements for assessing insight in patients with obsessive compulsive disorder (OCD) and to explore the relationships between insight and clinical variables. Materials and Methods: One hundred and twenty-ive subjects diagnosed with OCD were assessed for the measurement of insight with Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) insight criterion, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Brown Assessment of Beliefs Scale (BABS). The fourth question of Y-BOCS (resistance to obsessions) was taken as proxy measure of insight. In addition to Y-BOCS, Global Obsessive-Compulsive Symptom Severity Scale was applied to determine the clinical severity of OCD. Hamilton Depression Rating Scale (HDRS) was used to ind out severity of depressive symptoms. Results: Correlation coeficients indicated high concordance between insight as measured by Y-BOCS and BABS. The insight criterion of DSM-IV-TR had good concordance with BABS, but not with Y-BOCS. When the relationship of insight as assessed by different methods with other variables was assessed, it was seen that patients with poorer insight as per Y-BOCS had higher severity of OCD and depression, but insight assessed by other measures had no correlation with severity and comorbid depression. Conclusions: Dimensional measurement of insight in patients with OCD may be more useful. Comparison of familism in caregivers of patients with psychotic and affective disorders Aditya Hegde, Subho Chakrabarti, Sandeep Grover Department of Psychiatry, PGIMER, Chandigarh. E-mail: drsandeepg2002@ yahoo.com Background: Familism, the precedence given to family needs over needs of the individual, has been suggested as an important variable inluencing caregiving in persons with mental illness. Aim: To assess and compare familism in primary caregivers of patients with psychotic and affective disorders. Materials and Methods: Thirty-two caregivers of patients with psychotic disorders and 39 caregivers of patients with affective disorders were evaluated on the Familism Scale (Sabogal et al., 1987). Patients in both the groups were matched on gender, age, marital status, education, occupation, religion, type of family, and level of functioning (as assessed by using Global Assessment of Functioning Scale). Caregivers were matched on gender, age, marital status, education, and occupation. Results: A signiicantly greater number of patients in the affective disorder group came from a rural background (P-value 0.022). A signiicantly larger number of patients in the psychotic disorder group were unmarried (P-value 0.001). With respect to familism, the two groups did not differ signiicantly on the scores obtained on the three subscales or the total score on the Familism Scale. Conclusions: The type of psychiatric disorder does not inluence the precedence given to family needs over needs of the individual. A study on oxidative stress in patients of major depressive disorder Aditya Somani, PK Dalal, Madhu Dikshit, SM Natu, JK Trivedi, Bandna Gupta King George’s Medical University, Lucknow, Uttar Pradesh, India Background: Dysregulations of oxidative and nitrosativepathway, inlammatory pathway, 3 and hypothalamic-pituitary-adrenal (HPA) axis have been associated with major depressive disorder (MDD). Aims: 1. To assess and compare levels of neuronal nitric oxide synthase (nNOS), nitrite levels, reactive oxygen species (ROS),andmyeloperoxidase (MPO) in polymorphonuclear leukocytes (PMNs), plasma nitrite level, and serum cortisol in drug naive patients (in current episode) of MDD; their irst degree relatives and healthy controls. 2. To study the relation between clinical proiles of these patients with above parameters. Materials and Methods: • Drug naive patients of MDD diagnosed as per Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision(DSM-IV-TR), one of their healthy irst degree relatives and healthy controls were selected. • Patients were assessed on Hamilton Rating Scales for Depression (HAM-D) and Global Assessment of Functioning (GAF). Relatives and controls were screened with General Health Questionnaire12- item (GHQ-12). • Physical illnesses were ruled out. • Investigations were carried out in neutrophils, plasma, and serum. Results: • Study showed increased levels of ROSand serum cortisol, and decreased level of plasma nitrite in patients of MDD compared to controls. • Cortisol was increased in relatives of patients. • Levels of nNOS, neutrophil nitrite, and MPOwere not altered. • Signiicant correlation was not found between any of the investigational parameters and clinical proile. Discussions: • Increased ROS generation and decreased plasma nitrite indicate altered functioning of oxidative and nitrosative pathway in patients of MDD. • Nitric oxide pathway is not contributing to oxidative stress in given set of patients. • Normal expression of MPOcould be due to raised cortisol in given set of patients. Conclusions: • Plasma nitrite and serum cortisol could be useful peripheral biomarkers of depression. • Alternative sources of oxidative stress need to be explored. Effect of resilience on internet use: A study on medical undergraduates Amrita Chakraborti, Prasenjit Ray, Mehboob Ul Islam, Asim Kumar Mallick Department of Psychiatry, Burdwan Medical College, Burdwan, West Bengal, India Aims: Internet addiction is yet to be recognized as a diagnostic entity, but growing concern is being observed in Asian countries. Studies conducted in Indian city recognizes a large number of youth at risk of developing pathological internet use (Yadav, 2012). Correlates for these maladaptive digital preoccupation has been loneliness, stress, depression, lack of self-esteem, and poor resilience (Goel, 2013; Nalwa, 2003). Internet use is often increased in stressful life situation as it helps in mood regulation and social compensation, thereby temporarily FREE PAPERS (POSTERS) [Downloaded free from http://www.indianjpsychiatry.org on Tuesday, May 06, 2014, IP: 14.139.56.194] || Click here to download free Android application for this jour