Gene Section Review Atlas Genet Cytogenet Oncol Haematol. 2008;12(4) 282 Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS PEBP1 (phosphatidylethanolamine binding protein 1) Sandy Beach, Kam C Yeung Department of Cancer Biology and Biochemistry, College of Medicine, University of Toledo, Health Science Campus-(formerly Medical University of Ohio), 3035 Arlington Ave., Toledo, OH 43614, USA Published in Atlas Database: November 2007 Online updated version: http://AtlasGeneticsOncology.org/Genes/PEBP1ID44021ch12q24.html DOI: 10.4267/2042/38543 This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 2008 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Hugo: PEBP1 Other names: HCNP; HCNPpp; PBP; PEBP; PEBP-1; RKIP Location: 12q24.23 DNA/RNA Description The gene is composed of 4 exons spanning a region of 9,520 base pairs. Transcription The mRNA contains 1507 nucleotides. Alternative splicing has not been described. In prostate cancer cell lines RKIP transcription is repressed by Snail through an E-box in its promoter. Promoter methylation does not seem to cause loss of RKIP expression. Pseudogene RKIP has two putative pseudogenes located on chromosomes 2 and 14. These are intronless sequences with no verified expression to date. Diagram of the RKIP gene. Exons are depicted as filled boxes and untranslated regions are unfilled boxes. Introns are represented as lines between exons. Intron, exon, and untranslated region sizes are described in base pairs. Stereo view of the human RKIP structure prepared with Pymol (Delano, 2002). Pocket residues H86 (left), H118 (right), D70 (top) and Y120 (bottom) are indicated.