doi:10.1182/blood-2007-03-080796 Prepublished online September 18, 2007; Ifrah, Francois Dreyfus, Patrick Mayeux, Catherine Lacombe and Didier Bouscary Jerome Tamburini, Nicolas Chapuis, Valerie Bardet, Sophie Park, Pierre Sujobert, Lise Willems, Norbert pathways acute myeloid leukemia: rational for therapeutic inhibition of both mTORC1 inhibition activates PI3K/Akt by up-regulating IGF-1R signaling in (4217 articles) Neoplasia (1654 articles) Brief Reports Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication. the indexed by PubMed from initial publication. Citations to Advance online articles must include final publication). Advance online articles are citable and establish publication priority; they are appeared in the paper journal (edited, typeset versions may be posted when available prior to Advance online articles have been peer reviewed and accepted for publication but have not yet Copyright 2011 by The American Society of Hematology; all rights reserved. 20036. the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by For personal use only. by guest on June 10, 2013. bloodjournal.hematologylibrary.org From