19th World Congress on Ultrasound in Obstetrics and Gynecology Poster abstracts were rated to enable highly diagnostic confidence (82.9%), and produce better image quality for the near field image (94.3%), the far field image (88.6%), and overall (94.3%). Conclusions: The current study described an objective method of comparing image quality acquired using different sonographic technologies. Ultrasound transducer incorporated with PureWave Crystal technology produces significantly better image quality for diagnostic purpose. P11: FETAL ANEUPLOIDY SCREENING P11.01 Development and establishment of a national Danish fetal medicine database for quality surveillance and research C. K. Ekelund 1 , P. Skovbo 3 , A. Holmskov 4 , R. Farlie 5 , I. Stornes 6 , O. B. Petersen 2 , V. Ersbak 7 , S. Sommer 8 , S. Vemmelund 9 , H. Poulsen 10 , H. Mogensen 11 , C. Henriques 12 , H. J. Andersen 13 , T. Larsen 14 , L. Skibsted 16 , A. Kristiansen 15 , A. C. Shalmi 20 , A. Nikkil ¨ a 19 , L. Sperling 17 , H. Zingenberg 18 , F. Stener Jørgensen 21 , A. Tabor 1 1 Department of Fetal Medicine, Rigshospitalet, Copenhagen, Denmark; 2 Department of Fetal Medicine, Skjeby, Aarhus, Denmark; 3 Department of Fetal Medicine, Aalborg Sygehus, Aalborg, Denmark; 4 Department of Obstetrics and Gynecology, Viborg Sygehus, Viborg, Denmark; 5 Department of Obstetrics and Gynecology, Herning Sygehus, Herning, Denmark; 6 Department of Obstetrics and Gynecology, Randers Sygehus, Randers, Denmark; 7 Department of Obstetrics and Gynecology, Silkeborg Sygehus, Silkeborg, Denmark; 8 Department of Obstetrics and Gynecology, Horsens Sygehus, Horsens, Denmark; 9 Department of Obstetrics and Gynecology, Kolding Sygehus, Kolding, Denmark; 10 Department of Obstetrics and Gynecology, Esbjerg Sygehus, Esbjerg, Denmark; 11 Department of Obstetrics and Gynecology, Soenderborg Sygehus, Soenderborg, Denmark; 12 Department of Fetal Medicine, Odense Universitetshospital, Odense, Denmark; 13 Department of Obstetrics and Gynecology, Svendborg Sygehus, Svendborg, Denmark; 14 Department of Obstetrics and Gynecology, Holbæk Sygehus, Holbæk, Denmark; 15 Department of Obstetrics and Gynecology, Naestved Sygehus, Naestved, Denmark; 16 Department of Obstetrics and Gynecology, Roskilde Sygehus, Roskilde, Denmark; 17 Department of Fetal Medicine, Herlev Hospital, Herlev, Denmark; 18 Department of Fetal Medicine, Glostrup Hospital, Glostrup, Denmark; 19 Department of Obstetrics and Gynecology, Gentofte Hospital, Gentofte, Denmark; 20 Department of Obstetrics and Gynecology, Hilleroed Hospital, Hilleroed, Denmark; 21 Deaprtment of Fetal Medicine, Hvidovre Hospital, Hvidovre, Denmark Background: In 2004 the Danish Board of Health issued a new guideline on prenatal diagnosis and screening. Pregnant women are offered a first trimester combined risk assessment for T21 and a second trimester anomaly scan. Denmark has a public hospital system where 21 departments perform screening in pregnancy, all using the same software system, Astraia, to store screening data. The yearly number of deliveries is 65,000 and the uptake of screening is higher than 92%. The Database IT solution has been developed in close cooperation with Astraia gmbh, Germany and Center of Clinical Quality, Bispebjerg University Hospital, Denmark. The National Database: Figure 1 shows from where source data is collected. A web service client, using XML files daily transfers data from the local Astraia servers to the National Database Server. Cytogenetic information is retrieved from the National Cytogenetic Registry, which collects all pre- and postnatal karyotype diagnoses from the five chromosome laboratories in the country. Information about outcome of pregnancy and about anomalies diagnosed postnatally is retrieved from the Danish Patient Registry. All information is merged using the unique personal registration number every person in Denmark is given at birth. When the database is fully functional, each department can follow its own screening performance by using a web based analytical tool and explore own data using a statistical tool. The national data will be available for yearly quality reports and for research projects. We anticipate being able to retrieve data for 2008 in September 2009. Supporting information can be found in the online version of this abstract. P11.02 First-trimester combined screening for aneuploidy in a Brazilian population from a private center in Rio de Janeiro: a preliminary study L. M. Lopes 1 , F. M. Peixoto 1 , R. M. Sa 1 , A. A. Fonseca 2 , E. V. Neto 2 1 Maternal Fetal Medicine, Perinatal Group, Rio de Janeiro, Brazil; 2 Fetal Diagnosis, Diagnosticos Laboratoriais Especializados, Rio de Janeiro, Brazil Objective: The aim of this study was to assess the effectiveness of first-trimester screening using a combination of maternal age, nuchal translucency thickness (NT) and maternal serum free beta-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) levels for aneuploidy in a Brazilian population in Rio de Janeiro. Methods: This was a retrospective study of 546 women who underwent combined screening for aneuploidy between 11 + 0 and 13 + 6 weeks of gestation in a fetal medicine unit in Rio de Janeiro (Perinatal Group – Laranjeiras). NT was measured according to the criteria set by the Fetal Medicine Foundation (FMF). Maternal serum free β-hCG and PAPP-A levels were measured, and the risk of aneuploidy was calculated using The FMF’s algorithm. Fetal karyotyping was advised when the risk was 1: 100 or above. All subjects were followed up for pregnancy and fetal outcome. Results: Among the 546 women who underwent the screening program, 37% were 35 years old or above. 15 fetuses (2,7%) were screen positive; this included 2 cases of trisomy 21 and 1 case of trisomy 18. The sensibility was 75% and the specificity was 98%; the positive predictive value was 21%, and the negative predictive value was 99.5%. Among the 545 screen negative fetuses, there was only one case in which aneuploidy was missed and the infant was live born. Conclusion: First-trimester combined screening for aneuploidy was highly effective in the Brazilian population analyzed in this preliminary study. P11.03 First-trimester combined screening for aneuploidies in Taiwan C. Hsiao 1 Department of Obstetrics and Gynecology, Taipei City Hospital Women and Children Campus, Taipei, Taiwan; 2 Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan Objective: To evaluate the performance of first-trimester screening for aneuploides by using a combination of maternal age, nuchal translucency (NT), and maternal serum free β-human chorionic gonadotropin (free β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) and using NT screening only in Taiwanese of oriental population. Methods: This was a prospective study over 3 year period of 12,648 women who approached first-trimester screening between 11+0 and 13+6 weeks of gestation in 10 unit centers in Taiwan. There were 218 Ultrasound in Obstetrics & Gynecology 2009; 34 (Suppl. 1): 177–284