www.iajpr.com Page5185 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACTS OF CARISSA CARANDAS LINN Pooja Bhati, Ajay Shukla*, Maya Sharma, Pramod mourya Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy) Jabalpur M.P.Mohan Lal Sukhadiya University, Udaipur, Rajasthan,NRI Institutes of Pharmacy Bhopal, M.P. Corresponding author Ajay Shukla Research scholar Mohan Lal Sukhadiya University, Udaipur, Rajasthan House no. 1853/A Shakti nagar Gupteshwar Chowk Madan Mahal Jabalpur M.P. 482001 ashukla1007@gmail.com 919893735320 Copy right © 2014 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 16/10/2014 Available online 30/11/2014 Keywords Carissa Carandas, Hepatoprotective, Carbon Tetra Chloride. The Hepatoprotective activity of leaves of Carissa carandas linn against carbon tetra chloride induced hepatotoxicity in albino rats was determined. The leaves were collected and dried under shade followed by crushing. The extraction of crushed powder involve the Maceration by using methanol and acetone (w/v 1:3) solvent and concentrated to dry mass by using rotary vacuum evaporator. Dark green waxy residues (leaves) were collected separately. The different parameter of evaluation were taken such as histopathological studies, Total Bilirubin, Direct Bilirubin, SGPT and SGOT etc. The Liver section of animal which was treated with methanol and acetone (w/v 1:3) extract clearly shows the normal hepatic cells and compared with Silymarin treated group of animals. The result suggests that the methonolic extract of leaves of Carissa carandas linn possess a significant role as hepatoprotective activity. Please cite this article in press as Pooja Bhati et al. Hepatoprotective Activity of Leaves Extracts of Carissa carandas linn. Indo American Journal of Pharm Research.2014:4(11).