Haque et al., IJPSR, 2015; Vol. 6(10): 4336-4341. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 4336 IJPSR (2015), Vol. 6, Issue 10 (Research Article) Received on 04 April, 2015; received in revised form, 27 June, 2015; accepted, 15 September, 2015; published 01 October, 2015 STUDIES ON PHTHALIC ACID-PROPANE-1, 2-DIOL-GLYCEROL CO-POLYESTER AS AN ENTERIC COATING MATERIAL Md. Moinul Haque 1 , Md. Saiful Islam *2 , Anath Chandra Roy 1 and Md. Abu Bakr 2 Department of Applied Chemistry & Chemical Engineering 2 , Rajshahi University, Rajshahi-6205, Bangladesh. Department of Chemistry 1 , Dhaka City College, Dhaka-1205, Bangladesh ABSTRACT: Enteric coating material that, was synthesized in the laboratory and applied to a tablet and also drug release profile was investigated. A polymeric material - Phthalic acid propane-1,2 diol- glycerol co-polyester (PPGC) was synthesized from phthalic acid and propane-1, 2-diol with 5% glycerol of total weight as a crosslinking agent using Dean-Stark apparatus with Ferric Chloride as catalyst and o-xylene as the reaction medium. The polymer was dissolved in volatile organic solvent (Ethyl acetate) to prepare coating solution. The coating solution was sprayed over the DS tablet in a small coating pan with continuous hot air flow. The coating pan was allowed to rotate until the solvent evaporated and the tablet dried. The percentage of drug release from di-chlofenac sodium (DS) core and coated tablets (coated by phthalic acid-propane-1, 2-diol-glycerol co-polyester) instimulated gastric fluid (pH = 1.2) and in stimulated intestinal fluid (pH = 7.4), was investigated and according to B.P. standard drug release profile was obtained. INTRODUCTION: The synthesis and development of biodegradable polymer is one of the leading frontiers of research in polymer science of present time. Linear polyester such as poly lactic acid, poly glycolic acid etc. and network polyesters such as citric acid glycerol co-polyester are biodegradable and they are used for specialized applications, such as controlled drug formations, insecticide, pesticide and fertilizer carries as well as nontoxic surgical implant materials. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.6(10).4336-41 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.6(10).4336-41 Tablet coating is recently a moderation of tablet formulation. Coating may be done defined as the process of compressing a granulating layer around the performed tablets. It is an additional step for manufacturing of tablets. Tablets are originally for the sake of pharmaceutical elegance by improving appearance, test and solubility. More recently coating has been used to control the site of drug release (Enteric coating) 1, 2, 3 and delay or prolong the release of drug from the dosage form (sustained action) hence the absorption of drug present. The nature of coating varies; it may be simple or complex. In its simplest form it may merely consist of a thin film of varnish, applied to make the tablet dust free and reduce any bitter taste. In most complex form it may consist of inner and outer Keywords: Enteric coating material, Phthalic acid propane-1,2 diol- glycerol co-polyester, Drug release, Diclofenac sodium (DS), Intestinal fluid, Gastric fluid Correspondence to Author: Md. Saiful Islam Lecturer Department of Applied Chemistry & Chemical Engineering, Rajshahi University, Rajshahi-6205, Bangladesh. E-mail: saiful@ru.ac.bd