Targeted Disruption of Hepatic Frataxin Expression Causes Impaired Mitochondrial Function, Decreased Life Span, and Tumor Growth in Mice René Thierbach, 3,§ Tim J. Schulz, 1,§ Frank Isken, 2 Anja Voigt, 1,3 Brun Mietzner, 1 Gunnar Drewes, 1,3 Jürgen-Christoph von Kleist-Retzow, 4,5,6 Rudolf J. Wiesner, 4,6 Mark A. Magnuson, 7 Hélène Puccio, 8 Andreas F. H. Pfeiffer, 1,2 Pablo Steinberg, 3 Michael Ristow 1,2,# § These authors contributed equally to this work. # corresponding author, current address: University of Jena, Institute for Nutrition, Dept. of Human Nutrition, 29 Dornburger St., Jena 07743, Germany, phone: +49-3641-949630, fax: +49-3641-949632, email: michael.ristow@mristow.org 1 German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal-Berlin 14558, Germany 2 Charité University Medicine, Campus Benjamin Franklin, Berlin 12200, Germany 3 Institute for Nutrition, Dept. of Nutritional Toxicology, University of Potsdam, Nuthetal-Berlin 14558, Germany 4 Institute for Vegetative Physiology, University of Cologne, Cologne 50931, Germany 5 Clinic for Paediatric Medicine, University of Cologne, Cologne 50924, Germany 6 Centre for Molecular Medicine Cologne, University of Cologne, Cologne 50924, Germany 7 Vanderbilt University, Nashville, TN 37232, USA 8 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67404, France © The Author 2005. Published by Oxford University Press. All rights reserved HMG Advance Access published November 9, 2005 by guest on November 28, 2015 http://hmg.oxfordjournals.org/ Downloaded from