RESEARCH ARTICLE The Association of the Dopamine Transporter Gene and the Dopamine Receptor 2 Gene With Delirium, a Meta-Analysis Barbara C. van Munster, 1,2 * Sophia E.J.A. de Rooij, 2 Mojgan Yazdanpanah, 3 Pentti J. Tienari, 4 Kaisu H. Pitk€ al€ a, 5 Robert J. Osse, 6 Dimitrios Adamis, 7 Orla Smit, 8 Marijke S. van der Steen, 9 Miriam van Houten, 10 Terhi Rahkonen, 11 Raimo Sulkava, 11 Jouko V. Laurila, 12 Timo E. Strandberg, 13 Joke H.M. Tulen, 6 Louwerens Zwang, 14 Alastair J.D. MacDonald, 15 Adrian Treloar, 16 Eric J.G. Sijbrands, 3 Aeilko H. Zwinderman, 1 and Johanna C. Korevaar 1 1 Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands 2 Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands 3 Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands 4 Department of Neurology, Helsinki University Central Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland 5 Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland 6 Department of Psychiatry, Erasmus MC, Rotterdam, the Netherlands 7 Psychiatry, Research and Academic Institute of Athens, Athens, Greece 8 Department of Internal Medicine, VU Medical Center, Amsterdam, the Netherlands 9 Intensive Care, Gelderse Vallei Hospital, Ede, the Netherlands 10 Department of Geriatrics, Parnassia, Den Haag, the Netherlands 11 Department of Geriatrics, School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland 12 Helsinki University Central Hospital, Clinics of General Internal Medicine and Geriatrics, Helsinki, Finland 13 Oulu University Hospital, Unit of General Practice, Oulu, Finland 14 Department of Clinical Chemistry, Erasmus MC, Rotterdam, the Netherlands 15 Elderly Care Unit, St Thomas’ Hospital, Westminster, London, UK 16 Memorial Hospital, Shooters Hill, London, UK Received 22 May 2009; Accepted 5 August 2009 Additional Supporting Information may be found in the online version of this article. Practical realization: Data collection: Amsterdam: B.C. van Munster, S.E.J.A. de Rooij and research nurses of the Department of Medicine, Academic Medical Center, Amsterdam. Haarlem: M.S. van der Steen, O. Smit, M. van Houten, B.C. van Munster, S.E.J.A. de Rooij Helsinki: K.H. Pitk€ al € a, J.V. Laurila, T.E. Strandberg and research nurses. London: D. Adamis, A.J.D. Macdonald, A. Treloar Rotterdam: R.J. Osse Vantaa: R. Sulkava, T. Rahkonen, P. Tienari. Genotyping: Research technician L.C. van der Zee of the Lipid Clinic, Department of Internal Medicine under supervision of Dr. M. Yazdanpanah and Dr. E.J.G. Sijbrands. Data analysis: B.C. van Munster under supervision of J.C. Korevaar, M. Yazdanpanah, and A.H. Zwinderman. Writing: All of the above contributed to the writing of the manuscript. *Correspondence to: Barbara C. van Munster, M.D., Department of Internal Medicine, Academic Medical Centre, Room F4-259, P.O. Box 22660, 1100 DD Amsterdam, the Netherlands. E-mail: b.c.vanmunster@amc.uva.nl Published online 8 September 2009 in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/ajmg.b.31034 How to Cite this Article: van Munster BC, de Rooij SEJA, Yazdanpanah M, Tienari PJ, Pitk€ al € a KH, Osse RJ, Adamis D, Smit O, van der Steen MS, van Houten M, Rahkonen T, Sulkava R, Laurila JV, Strandberg TE, Tulen JHM, Zwang L, MacDonald AJD, Treloar A, Sijbrands EJG, Zwinderman AH, Korevaar JC. 2010. The Association of the Dopamine Transporter Gene and the Dopamine Receptor 2 Gene With Delirium, a Meta-Analysis. Am J Med Genet Part B 153B:648–655. Ó 2009 Wiley-Liss, Inc. 648 Neuropsychiatric Genetics