Wolberg 1 Image Analysis and Machine Learning Applied to Breast Cancer Diagnosis and Prognosis William H. Wolberg M.D. 1 , W. Nick Street M.S. 2 , and Olvi L. Mangasarian Ph.D. 3 From the Departments of Surgery, Human Oncology and Computer Sciences, University of Wisconsin, Madison, Wisconsin, U.S.A. This study was supported in part by Air Force Office of Scientific Research grant AFOSR 89-0410 and National Science Foundation grant CCR-9101801. Address reprint requests to: William H. Wolberg, M.D. Department of Surgery, University of Wisconsin Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792 1 Dr. Wolberg is Professor, Departments of Surgery and Human Oncology, University of Wisconsin, Madison, WI 53792 2 Mr. Street is a Ph.D. student and Research Assistant, Computer Sciences Department, University of Wisconsin, Madison, WI 53706 3 Dr. Mangasarian is Professor, Computer Sciences Department, University of Wisconsin, Madison, WI 53706