Addressing Uncertainty in Clinical Guidelines: Info-Gap Decision Theory for LDL Cholesterol Management Jon Carrasco, B.A. 1 , Nithin Rajan, B.A. 1 , Theresa Brown, B.A. 1 , Yakov Ben-Haim, Ph.D. 2 and Clifford C. Dacso, M.D., M.P.H. 3 Running head: Info-Gap Theory for Managing Cholesterol Work performed at: (1) Abramson Center for the Future of Health of the Methodist Hospital Research Institute and the University of Houston, Houston, Texas. (2) Faculty of Mechanical Engineering, Technion—Israel Institute of Technology, Haifa, Israel. Financial support: Abramson Center for the Future of Health of the Methodist Hospital Re- search Institute and the University of Houston, Houston, Texas. Corresponding author: Yakov Ben-Haim, Faculty of Mechanical Engineering, Technion—Israel Institute of Technology, Haifa, 32000 Israel. 0 \people\dacso\Guidelines\gl10.tex. c  Clifford C. Dacso and Yakov Ben-Haim 10.3.2008 1 Finger Fellow, Abramson Center for the Future of Health, Houston, Texas 2 Yitzhak Moda’i Chair in Technology and Economics, Technion—Israel Institute of Technology, Haifa 32000 Israel, yakov@technion.ac.il 3 John S. Dunn Sr. Research Chair in General Internal Medicine, The Methodist Hospital Research Institute, Distinguished Research Professor, University of Houston, CDacso@tmhs.org 1