CASE REPORT Oral leiomyomatous hamartoma: A case report and review of literature Ana Carolina Scarpelli a , Myrna Jorda ˜o Coelho Novaes b , Tarcı ´lia Aparecida da Silva c , Carolina Cavalieri Gomes c , Joa ˜o Batista Novaes Jr. c , Ricardo Alves Mesquita c, * a Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antoˆnio Carlos 6627, Pampulha 31270-901, Belo Horizonte, Minas Gerais, Brazil b DDS, Pediatric Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antoˆnio Carlos 6627, Pampulha 31270-901, Belo Horizonte, Minas Gerais, Brazil c Department of Oral Surgery, Oral Medicine and Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antoˆnio Carlos 6627, Pampulha 31270-901, Belo Horizonte, Minas Gerais, Brazil Received 15 March 2007; received in revised form 21 May 2007; accepted 22 May 2007 Introduction Hamartoma, derived from the Greek word hamar- tanein (to fail, to err), is a benign tumor-like mal- formation manifested as a mass of an abnormal mixture of tissues indigenous to the site involved [1,2]. By definition, there is usually a relative over- growth of one element of the tissue, but without the tendency towards progressive growth found in benign neoplasm [3]. Hamartomas frequently affect the liver, spleen, kidneys, lungs, pancreas and maxillofacial region. Oral hamartomas are commonly of a vascular origin, e.g. lymphangiomas and hemangiomas. However, hamartoma of other tissues is rare in the mouth. Oral leiomyomatous hamartoma (OLH) is a nodular lesion present at birth, located on midline portion of the maxilla (incisive papilla), palate and tongue. It is com- posed of an ill-defined mass of small bundles of cells with a smooth muscle profile and nerve fibers [4—8]. International Journal of Pediatric Otorhinolaryngology Extra (2007) 2, 198—201 www.elsevier.com/locate/ijporl KEYWORDS Hamartoma; Leiomyomatous hamartoma; Smooth muscle; Congenital; Immunohistochemistry Summary This article presents the eighth case of the rare oral leiomyomatous hamartoma, located on the midline of the maxillary alveolar ridge in an otherwise healthy 6-month-old girl. The lesion had been present since birth. After surgical excision, the specimen was submitted for histological and immunohistochemical evaluation. No recurrence was observed 6 months after excision. # 2007 Elsevier Ireland Ltd. All rights reserved. * Corresponding author at: Faculdade de Odontologia da UFMG, Disciplina de Patologia Bucal, sala 3204, Av. Anto ˆnio Carlos 6627, Pampulha 31270-901, Belo Horizonte-MG, Brazil. Tel.: +55 31 3499 2478/2479; fax: +55 31 3499 2472/2430. E-mail address: ramesquita@ufmg.br (R.A. Mesquita). 1871-4048/$ — see front matter # 2007 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.pedex.2007.05.009