International Journal of Pharmacy Teaching & Practices 2015, Vol.6, Issue 3, 2146-2150. 2146 Development of Metclopramide Floating Tablets Based on HPMC Matrices: A Comparison Study with Marketed Formulation Shammy Jindal*, Amit Sharma & Kamya Jindal Laureate Institute of Pharmacy, Kathog - Himachal Pradesh Research Article Please cite this paper as Shammy Jindal*, Amit Sharma & Kamya Jindal. Development Of Metclopramide Floating Tablets Based On Hpmc Matrices: A Comparison Study With Marketed Formulation. IJPTP, 2015, 6(3), 2146-2150. Abstract Objective: The objective of this study was to develop a floating matrix tablet of Metoclopramide based on HPMC matrices and check the effect of controlled release property of the drug with marketed formulation. Method: Tablets are prepared by wet granulation method by using HPMC, Sodium starch glycolate and sodium bicarbonate as polymers and excipients. PVP K 30 (5% in IPA) used as granulating agent. Results: Floating properties of the tablets were determined by determination of density, floating lag time, floating duration and in vitro drug release. Tablets of all the batches had desired buoyancy characteristics. Conclusion: It was concluded that upon increase in concentration of sodium bicarbonate and sodium starch glycolate in the HPMC matrices sustained the drug release. From the comparison studies it was found that developed formulation were more effective due to patient compliance. Keywords: Floating tablets, Floating drug delivery systems (FDDS), HPMC Matrices, Metclopramide Introduction Unpredictable gastric residence time (GRT) of a controlled release dosage form leads to interest in targeting and retaining the dosage form in the stomach for a prolonged period of time [1] . Thus Retention of drug delivery systems in the stomach prolongs overall gastrointestinal transit time and improves the oral bioavailability of the drugs that are having site-specific absorption from the stomach or upper part of the small intestine. Therefore different approaches have been proposed to retain the dosage form in the stomach including bioadhesive systems [2] , swelling and expanding systems [3-4] , floating systems [5-6] and delayed gastric emptying devices [7] . The principle of buoyant preparation offers a simple and practical approach to achieve increased gastric residence time for the dosage form and sustained drug release. Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration [8] . Metoclopramide Hydrochloride (MCP) is used as a model drug for the present study, to produce Floating drug delivery system. MCP is 4-amino-5- chloro-N-[2-(diethyl amino) ethyl]-2 methoxy benzamide monohydrochloride monohydrate. It is one of the potent antiemetic drugs. MCP apparently antagonizes dopamine at the receptor sites. This action can explain its sedative, central antiemetic (blocks dopamine in the chemo-receptor trigger zone), extrapyrimidal, and prolactin secretion stimulation effects. It is used to treat the emesis caused due to chemotherapy in cancer patient. Due to Dopamine (D2) receptor blocking action the drug is showing extra-pyramidal (Parkinsonism like) symptoms, if administered in conventional dosage forŵ ďut the patieŶt’s Đoŵpatiďility can be improved if administered in controlled release dosage form. Metoclopramide Hydrochloride is commonly used for the treatment of nausea and vomiting. This drug is highly water soluble and is rapidly absorbed after oral administration. It has a short biological half-life (5 ± 1 hour) and is usually administered in a dose of 10 to 15 mg four times daily in order to maintain effective concentrations throughout the day. In long term therapy, fluctuation in the plasma concentration, with high concentration peaks are common for drugs with rapid absorption and elimination. The secondary Corresponding Author: Shammy Jindal Laureate Institute Of Pharmacy, Kathog - Himachal Pradesh