CHEMISTRY Int.J.Curr.Res.Chem.Pharma.Sci.1(4):93-98
© 2014, IJCRCPS. All Rights Reserved 93
RESEARCH ARTICLE
SYNTHESIS AND CRYSTAL STRUCTURE OF (BIS [(2-AZANIUMYL-3-METHYLBUTANOYL)
OXY](
2
-BROMANIDYL)FERRIO)-
2
-BROMANIDE
M. RADHA RAMANAN
1
, P. GEETHA
2
, R. RADHAKRISHNAN
3
, V. CHITHAMBARAM
2
AND
B. GUNASEKARAN
4*
1
Department of Physics, Arasu Engineering College, Kumbakonam, Tamil Nadu, India.
2
Research Centre Physics, Dhanalakshmi College of Engineering, Tambaram, Chennai-600 059 Tamil Nadu,
India.
3
PG & Research Department of Physics, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, India.
4
Department of Physics & Nano Technology, SRM University, SRM Nagar, Kattankulathur, Kancheepuram
Dist, Chennai-603 203 Tamil Nadu, India.
*Corresponding Author: gunasekaran.b@ktr.srmuniv.ac.in; bguna_sekaran77@yahoo.co.in
Introduction
Amino acids play central role as building blocks of
proteins. Amino acids act not only as the building
blocks in protein synthesis but also play a
significant role in metabolism. The specific
metabolic role of amino acids includes the
biosynthesis of polypeptides, proteins and synthesis
of nucleotides (Barrett, 1988). The oxidation of
amino acids is of interest as different oxidation
products are obtained using different oxidants
(Laloo and Mahanti, 1990; Annapurna et al.,
2008). Valine is one of the 20 proteinogenic
(Ambrogelly et al., 2007) amino acid. L-Valine is
an essential amino acid classified as non-polar, and
forms active sites of enzymes and helps in
maintaining proper conformation by keeping them in
proper ionic states and wide applications in
pharmaceutical and food industry (Bartek et al.,
2010). Hence, oxidation of L-Valine may help in
understanding some aspects of enzyme kinetics.
Valine is a branched-chain amino acid (BCAAs)
along with leucine and isoleucine. It is named after
the plant valerian. In sickle-cell disease (Platt et al.,
1994), valine substitutes for the hydrophilic amino
acid glutamic acid in hemoglobin (Bruce et al.,
2006). Because valine has large aliphatic
hydrophobic side chains (Wang and L. Jiang,
2007), the hemoglobin does not fold correctly. It
promotes muscle growth and tissue repair. Many
workers (Andreoli, et al., 1984; Saxena and
Dhawan, 1983) have studied biologically active
metal complexes of amino acids which are
important in analytical, biochemical and
pharmaceutical fields (Patel, et al., 1996; Khan
and P.L. Sahu, 2000; Singh, et al., 1995) and
attracted wide attention in different fields of
International Journal of Current Research in
Chemistry and Pharmaceutical Sciences
www.ijcrcps.com Volume 1 Issue: 4 2014 Pages:93-98
(p-ISSN: 2348-5213; e-ISSN: 2348-5221)
Abstract
The crystal structure of the title compound has been determined by means of X-Ray diffraction. The compound
crystallizes in the triclinic space group P1 with a = 6.173 (2) Å, b = 8.202 (3) Å, c = 9.613 (4) Å and = 76.217 (2), =
83.006 (2), = 68.474 (3) º. The terminal methyl groups of L-valine moiety is disordered over two positions with site
occupancies of 0.51/0.49 and 0.63/0.37. The crystal packing of the compound is controlled by weak intermolecular C-
H…O and N-H…O and N-H…Br interactions.
.
Keywords: single-crystal X-ray study, L-valine, disorder, R factor = 0.037.