Hindawi Publishing Corporation BioMed Research International Volume 2013, Article ID 284821, 7 pages http://dx.doi.org/10.1155/2013/284821 Clinical Study Epiretinal Membranes in Patients with Uveitis: Morphological and Functional Analysis with Spectral Domain Optical Coherence Tomography Ludovico Iannetti, 1,2 Paolo Tortorella, 1 Enzo D’Ambrosio, 1 Rossela Spena, 1 Roberta Zito, 1 and Magda Gharbiya 1 1 Department of Ophthalmology, Sapienza University of Rome, 15500161 Rome, Italy 2 Servizio di Immunovirologia Oculare, Sapienza Universit` a di Roma, Viale del Policlinico, 15500161 Rome, Italy Correspondence should be addressed to Ludovico Iannetti; l.iannetti@policlinicoumberto1.it Received 9 April 2013; Revised 22 September 2013; Accepted 22 September 2013 Academic Editor: Timothy Y. Lai Copyright © 2013 Ludovico Iannetti et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD- OCT) with visual acuity (VA). Methods. Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed in all patients and data were collected at the time of ERM diagnosis and at the inal visit. Both best corrected visual acuity (BCVA) and ERM thickness were correlated with the morphological and clinical features. Results. Final BCVA was positively correlated with male sex ( = 0.0055) and the focal pattern of ERM attachment ( = 0.031) and negatively correlated with IS/OS photoreceptor junction disruption ( = 0.042). BVCA change showed a positive correlation with the age of ERM onset ( = 0.056) but a negative correlation with IS/OS photoreceptor disruption at the ERM diagnosis ( = 0.029) and the increase of central subield thickness (CST) ( = 0.95). Final ERM thickness correlated with the duration of uveitis ( = 0.0023) and the duration of ERM ( = 1.15 e-05). During the follow-up, ERM thickening correlated with male sex ( = 0.042), posterior uveitis ( = 0.036), uveitis duration ( = 0.026), and broad attachment pattern ( = 0.052). Conclusions. In the uveitic ERM, VA negatively correlates with IS/OS photoreceptor junction disruption and the increase of CST. ERM thickness is inluenced by longer duration of both uveitis and ERM. 1. Introduction Macular epiretinal membrane (ERM) is a pathology caused by a ibrocellular proliferation on the inner limiting mem- brane (ILM), followed by cellular contraction. ERM can be either idiopathic or secondary to vitreoretinal diseases, such as proliferative vitreoretinopathy (PVR), diabetic retinopa- thy, and intraocular inlammation. Idiopathic ERM forma- tion is thought to be secondary to glial cell migration, which may require some involvement of retinal pigment epithelial (RPE) cells. On the other hand, the absence of RPE cells and the abundance of inlammatory cells are characteristics of ERM as secondary to uveitis [1]. Contraction of ERM causes a signiicant macular dys- function and is accompanied by the following symptoms: (i) metamorphopsia, (ii) severe visual reduction, and occasion- ally (iii) central unilateral diplopia [2–4]. Optical coherence tomography (OCT) has become the standard diagnostic technique used to evaluate uveitic macular edema and other pathologies involving the macula in patients with uveitis. he improved resolution and image quality, along with the ease of obtaining these images, have augmented its signiicance for macular diagnostics in uveitis practice. OCT is suitable for detecting and monitoring uveitic macular edema and provides important information about the luid distribu- tion in eyes with macular edema as well as revealing the morphology of the vitreoretinal interface. hree diferent patterns of luid distribution in the macula of patients with uveitis have been described as follows: cystoid macular edema (CME), difuse macular edema (DME), and serous retinal