e119 Med Oral Patol Oral Cir Bucal. 2010 Jan 1;15 (1):e119-25. Early bone healing to variations in RBM surfaces Journal section: Biomaterials and Bioengineering in Dentistry doi:10.4317/medoral.15.e119 Publication Types: Research Early bone healing around implant surfaces treated with variations in the resorbable blasting media method. A study in rabbits Ryan Jeong 1 , Charles Marin 2 , Rodrigo Granato 3 , Marcelo Suzuki 4 , Jose N Gil 5 , Jose M. Granjeiro 6 , Paulo G. Coelho 7 1 Research Assistant, Dept of Biomaterials and Biomimetics, New York University, New York, USA 2 Instructor, Dept. of Oral and Maxillofacial Surgery, Pontiicia Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil 3 Research Scientist, Department of Dentistry, Oral and Maxillofacial Surgery, Universidade Federal de Santa Catarina, Flori- anopolis, Brazil 4 Assistant Professor, Tufts University School of Dental Medicine, Boston, USA 5 Associate Professor, Department of Dentistry, Oral and Maxillofacial Surgery, Universidade Federal de Santa Catarina, Flori- anopolis, Brazil 6 Professor, Department of Cell and Molecular Biology, Universidade Federal Fluminense, Niteroi, Brazil 7 Assistant Professor, Dept of Biomaterials and Biomimetics, New York University, New York, USA Correspondence: 345 24th street room 813a New York, NY 10010 pgcoelho@nyu.edu Received: 13/07/2009 Accepted: 02/08/2009 Jeong R, Marin C, Granato R, Suzuki M, Gil JN, Granjeiro JM, Coelho PG. Early bone healing around implant surfaces treated with variations in the resorbable blasting media method. A study in rabbits. Med Oral Patol Oral Cir Bucal. 2010 Jan 1;15 (1):e119-25. http://www.medicinaoral.com/medoralfree01/v15i1/medoralv15i1p119.pdf Abstract Objective: this study aimed to histomorphologically and histomorphometrically evaluate the in vivo response to three variations in the resorbable blasting media (RBM) surface processing in a rabbit femur model. Study De- sign: screw root form implants with 3.75 mm in diameter by 8 mm in length presenting four surfaces (n=8 each): alumina-blasted/acid-etched (AB/AE), bioresorbable ceramic blasted (TCP), TCP + acid etching, and AB/AE + TCP were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The im- plants were placed at the distal femur of 8 New Zeland rabbits, remaining for 2 weeks in vivo. After sacriice, the implants were nondecalciied processed to 30 micro m thickness slides for histomorphology and bone-to-implant contact (BIC) determination. Statistical analysis was performed by one-way ANOVA at 95% level of signiicance considering implant surface as the independent variable and BIC as the dependent variable. Results: SEM and AFM showed that all surfaces presented rough textures and that calciu-hosohate particles were observed at the TCP group surface. Histologic evaluation showed intimate interaction between newly formed woven bone and all implant surfaces, demonstrating that all surfaces were biocompatible and osseoconductive. Signiicant differences in BIC were observed between the AB/AE and the AB/AE + TCP, and intermediate values observed for the TCP and TCP + Acid surfaces. Conclusion: irrespective of RBM processing variation, all surfaces were osseoconduc- tive and biocaompatible. The differences in BIC between groups warrant further bone-implant interface biome- chanical characterization. Key words: Dental implant, surface treatment, resorbable blasting media, in vivo. Article Number: 3026 http://www.medicinaoral.com/ © Medicina Oral S. L. C.I.F. B 96689336 - pISSN 1698-4447 - eISSN: 1698-6946 eMail: medicina@medicinaoral.com Indexed in: -SCI EXPANDED -JOURNAL CITATION REPORTS -Index Medicus / MEDLINE / PubMed -EMBASE, Excerpta Medica -SCOPUS -Indice Médico Español