10–14 October 2010, Prague, Czech Republic Short oral presentation abstracts Digital analysis of the placenta was performed using ‘Image J’ software (http://rsb.info.nih.gov/ij). Placentas were weighed, and measurements were taken of the placental axes and, those intersecting the cord insertion. We derived: eccentricity index (range 0–1) describing the shape of the placenta; cord centrality index (CCI) (range 0–1) describing the distance of umbilical cord insertion from the centre of placenta and coiling index describing the number of coils per cm length of umbilical cord. Results: See Table 1. Conclusions: Studies have shown the smaller placentas for smaller babies and other morphological abnormalities of placenta in IUGR cases. Low birth weight has also been associated with hypercoiling of the cord and peripheral insertion of the umbilical cord. This study did not show any difference in placental indices for babies with birth weight percentile ≤ 10 th compared to a reference population. OP29.02: Table 1 IUGR ≤ 10 th centiles) (n = 60) Mean (SD) Reference population (n = 888) Mean (SD) Birth weight: placental weight ratio 7.26 (1.32) 7.41 (1.18) Eccentricity 0.52 (0.18) 0.49 (0.18) Cord centrality index 0.40 (0.23) 0.36 (0.21) Coiling index 0.22 (0.11) 0.20 (0.09) OP29.03 The evaluation of placental volume and placental bed blood flow dynamic by real-time 3D ultrasonography W. Gou The First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xian, China Objectives: The purpose of this study was to construct nomograms of placental volumes according to gestational age and evaluate double uterine artery dynamic index, placental bed blood flow dynamic index. Methods: From June to December 2009, placental volumes were prospectively measured by ultrasonography in 516 normal pregnancies from 11 to 24 weeks, gestation and correlated with gestational age. Inclusion criteria were healthy women, singleton pregnancies with normal fetal morphologic characteristics on ultrasonography, and confirmed gestational age by first-trimester ultrasonography. Results: 1. Linear regression yielded the following formula for the placental volumes (PV) according to gestational age (GA) PV(cm 3 ) =−92.659 + 1.826 × GA (r = 0.586, P < 0.01). 2. PI, RI, S/D of Double uterine artery correlated with gestational age. 3. RI of placental bed artery correlated with gestational age; 4. The mean PI of placental bed artery was 0.49 ± 0.23. Conclusions: Nomograms of placental volumes according to gestational age. OP29.04 3-Dimensional power Doppler angiography of placenta in normal and growth restricted fetuses A. Rossi , G. Fachechi, L. Forzano, A. Balsamo, A. Arteni, D. Marchesoni Universit ` a di Udine, Clinica Ostetrico-Ginecologica Udine, Udine, Italy Objectives: The aim of this study was to investigate placental vascular sonobiopsy using 3D power Doppler angiography (3D PDA) to assess placental vascularisation in normal and growth restricted fetuses (IUGR). Methods: Placental vascular sonobiopsy was performed on 90 healthy singleton pregnancies and on 35 pregnancies with fetal growth restriction between 22–37 weeks of gestation. 3D power Doppler indices related to placenta vascularization (vascularization index, flow index, vascularization flow index) were calculated in each placenta. Results: Placental perfusion in pregnancies presenting foetuses affected by IUGR was reduced compared with normal pregnancies. We also demonstrated a correlation between vascular indices of placenta and fetal weight. Besides FI, which identifies the most severe cases of placental impairment, appears to be the most reliable index because of its low intraplacental variability. Conclusions: Our findings suggest that the study of placenta with 3D PDA can provide information on placental pathophysiology. In clinical practice this information could be an adjunct to umbilical artery Doppler studies in the valuation of fetuses affected by IUGR. OP29.05 Renal blood perfusion measured by fractional moving blood volume and spectral Doppler pulsatility index in fetuses with intrauterine growth restriction R. Cruz-Martinez , F. Figueras, M. C. Cruz Lemini, E. Hernandez-Andrade, E. Gratac ´ os Department of Maternal-Fetal Medicine, Hospital Clinic, Barcelona, Spain Objectives: The existence of blood flow renal changes in intrauterine growth restriction (IUGR) is controversial. We evaluated changes in renal blood perfusion in fetuses with early-onset IUGR and term small-for-gestational-age (SGA). Methods: Renal perfusion measured by fractional moving blood volume (FMBV) and renal artery (RA) Doppler pulsatility index (PI) were assessed in a cohort of 22 consecutive early-onset (< 34 weeks) IUGR fetuses with abnormal umbilical artery (UA) PI (> 95 th percentile), 24 consecutive term (> 37 weeks) SGA fetuses with normal UA Doppler, and 46 AGA fetuses matched by gestational age with cases. Results: IUGR fetuses showed no significant differences in renal FMBV (18.5% vs. 17.9%, P = 0.72) and RA PI (2.5 vs. 2.4, P = 0.72) than controls. Likewise, SGA fetuses showed similar values than controls in renal FMBV (19.1% vs. 21.6%, P = 0.28) and RA PI (2.4 vs. 2.2, P = 0.10). Conclusions: Renal blood perfusion as measured by FMBV or by spectral Doppler PI is unchanged in IUGR and SGA fetuses with respect to AGA fetuses. OP29.06 Umbilical artery PI and fetal abdominal circumference in gastroschisis U. Hussain 1 , A. Daemen 4 , H. Missfelder-Lobos 1 , D. Timmerman 3 , T. Bourne 2,3 , B. de Moor 4 , C. Lees 1 1 Fetal Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom; 2 Institute of Development and Reproductive Biology (IRDB), Imperial College London, London, United Kingdom; 3 Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium; 4 Department of Electrical Engineering (ESAT), Katholieke Universiteit, Leuven, Belgium Objectives: To determine whether a relationship exists between umbilical artery PI (UAPI) and the fetal abdominal circumference (AC) measurement in isolated gastroschisis. Methods: Data from 58 pregnancies 24–36 weeks with isolated gastroschisis were included; in 52, UAPI was recorded on 2 or more scans. Z-scores were calculated for UAPI and AC values compared to normal pregnancies according to a standard ranges. Functional linear discriminant analysis (FLDA) was applied, resulting in spline curves fitted through all data points belonging to each subject. The median number of data points per subject was calculated, this number of points was randomly selected from each individual curve Ultrasound in Obstetrics & Gynecology 2010; 36 (Suppl. 1): 52–167 137