IJBPAS, April, 2012, 1(3): 382-394 ISSN: 2277–4998 382 382 382 382 IJBPAS, April, 2012, 1(3) IJBPAS, April, 2012, 1(3) IJBPAS, April, 2012, 1(3) IJBPAS, April, 2012, 1(3) CHEMICAL INHIBITOR FOR TANKYRASE 1 TO CONTROL CELL PROLIFERATION IN CANCER TRIPATHI AD 1 , SINGH J 2 AND SRIVASTAVA Y 3* 1: IT Centre (Authorized Training Centre of DOEACC and Shreeton India Ltd.) Harihar Prasad Dubey Marg, Betiyahata, Gorakhpur, 273001. 2: Division of Endocrinology, CDRI, Lucknow 3: Division of Molecular Oncology, Institute of Cytology and Preventive Oncology, Noida Corresponding Author: E Mail: yansh111@gmail.com Telomeres are repeated TTAGGG sequences that stop natural chromosome ends from behaving as random breaks, tankyrase 1 upregulation, decrease the TRF1-TIN2-TPP1-POT1 loading on a chromosome end, attenuates the impact of telomerase inhibitors by allowing access of residual telomerase activity. Conversely, blockade of tankyrase1 enhances the effect of telomerase inhibitors, whereas tankyrase1 removes the telomeric protein complex by poly (ADP-ribosyl) ating TRF1. In cancerous cells protein tankyrase1 binds with Trf1 , resulting in degradation of Trf1complex (sheltrin) on telomeres ,which allows telomerase binding on telomere proceeding a un controlled replication , to tackle this we had taken tankyrase1 as a target, PARP domain (PDB ID: 2RF5) of tankyrase1 is responsible for trf1’s poly(ADP-ribosyl)ation and degradation of sheltrin in cancerous cells, to inhibit activity of PARP domain docking is performed to find the inhibitors for PARP domain, docking predicted 13 different ligands showing docking with 2RF5, out of these Acetoxy(4-aminophenyl)mercury is predicted best on the basis of its energy and dock score. Keywords: Telomere, Sheltrin, Telomerase, Tankyrase 1, PARP INTRODUCTION The Telomere shortening theory of aging implies that cell death is caused by telomere shortening, during each cell division, the role of telomeres is to assist, complete replication