Accepted Article Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation Olaf Merkel 1,3,10,11 , Frank Hamacher 2,11 , Robert Griessl 2 , Lisa Grabner 3 , Ana-Iris Schiefer 3 , Nicole Prutsch 3 , Constance Baer 4 , Gerda Egger 3,10 , Michaela Schlederer 3,7 , Peter William Krenn 2 , Tanja Nicole Hartmann 2 , Ingrid Simonitsch- Klupp 3 , Christoph Plass 4 , Philipp Staber 5 , Richard Moriggl 7,9 , Suzanne D. Turner 6,10 , Richard Greil 2 , Lukas Kenner 3,7,8,10 1. Department of Translational Oncology, National Center for Tumor Diseases (NCT) German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany 2. Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Oncologic Center, Paracelsus Medical University Salzburg, Müllner Hauptstrasse 48, 5020 Salzburg, Austria 3. Department of Clinical Pathology, Medical University Vienna, Währinger Gürtel 18-20, 1090 Wien, Austria 4. Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany 5. Department of Medicine I, Medical University Vienna, Währinger Gürtel 18-20, 1090 Wien, Austria 6. Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Lab Block Level 3, Box 231, Addenbrooke’s Hospital, Cambridge CB20QQ, United Kingdom 7. Ludwig Boltzmann Institute for Cancer Research, Währingerstrasse 13a, 1090 Wien, Austria 8. Unit of Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, 1210 Vienna, Austria 9. Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria; Medical University of Vienna, Vienna, Austria 10. European Research Initiative on ALK Related Malignancies (www.erialcl.net) 11. These authors contributed equally to the manuscript Key words: miR-155, ALCL, ALK kinase, cytokines, IL-21, IL-22, IL-10 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/path.4539 This article is protected by copyright. All rights reserved.