Histo-Genomic Stratification Reveals the Frequent Amplification/Overexpression of CCNE1 and BRD4 Genes in non-BRCAness High Grade Ovarian Carcinoma Oumou Goundiam 1,2,3,* , Pierre Gestraud 4,9,10,* , Tatiana Popova 5* , Thibault De la Motte Rouge 6 , Virginie Fourchotte 7 , David Gentien 3 , Philippe Hupé 4,9,10,11 , Véronique Becette 1 , Claude Houdayer 1,5,8 , Sergio Roman-Roman 3 , Marc-Henri Stern 1, 5 , Xavier Sastre-Garau 1,2 . 1 Department of Biopathology, Institut Curie, Paris 2 EA4340-BCOH, Versailles Saint-Quentin-en-Yvelines University, Guyancourt 3 Department of Translational Research, Institut Curie, Paris 4 Bioinformatics and Computational Systems Biology of Cancer, Institut Curie, Paris 5 Inserm U830 Institut Curie, Paris 6 Department of Medical Oncology, Institut Curie, Paris 7 Department of Surgery, and on behalf of the Gynecologic Study Group, Institut Curie, Paris 8 Université Paris Descartes, Sciences Pharmaceutiques et Biologiques, Sorbonne Paris Cité, Paris, France 9 Mines Paris Tech 10 Inserm U900 11 CNRS UMR 144 *Equally contributors to this work Using an integrative genomic/expression analysis, we validate in epithelial ovarian cancer (EOC) a BRCAness genomic signature reported for basal-like/triple negative breast cancer and show that recurrent amplification/overexpression of potential target genes segregate preferentially in non-BRCAness EOC. We describe for the first time that BRD4, a therapeutic target in several tumor models, is amplified/overexpressed in 15-20% of non-BRCAness EOC. We identify subgroups of EOC that may benefit from specific therapies and confirm this result on the TCGA data set. Running title: Histo-Genomic Stratification of Ovarian Carcinomas Key words: ovarian cancer; genomics; BRCAness; CCNE1; BRD4 Abbreviations used: LST: Large-scale State Transitions ( hi = high ; lo = low) Article category: Cancer Genetics This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1002/ijc.29568 This article is protected by copyright. All rights reserved.