Clinical Study
A Randomised Controlled Trial to Delay or Prevent Type 2
Diabetes after Gestational Diabetes: Walking for Exercise and
Nutrition to Prevent Diabetes for You
A. S. Peacock,
1,2
F. E. Bogossian,
1
S. A. Wilkinson,
2,3
K. S. Gibbons,
2
C. Kim,
4
and H. D. McIntyre
3,5
1
School of Nursing and Midwifery, he University of Queensland, Brisbane, QLD 4067, Australia
2
Mater Research Institute, he University of Queensland, Brisbane, QLD 4101, Australia
3
Mater Health Services, Brisbane, QLD 4101, Australia
4
University of Michigan, Ann Arbor, MI 48109, USA
5
School of Medicine, he University of Queensland, Brisbane, QLD 4067, Australia
Correspondence should be addressed to A. S. Peacock; a.peacock2@uq.edu.au
Received 5 August 2014; Accepted 22 October 2014
Academic Editor: Anastasia Mavrogiannaki
Copyright © 2015 A. S. Peacock et al. his is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aims. To develop a program to support behaviour changes for women with a history of Gestational Diabetes Mellitus (GDM) and
a Body Mass Index (BMI) > 25 kg/m
2
to delay or prevent Type 2 Diabetes Mellitus. Methods. Women diagnosed with GDM in the
previous 6 to 24 months and BMI > 25 kg/m
2
were randomized to an intervention (I) ( = 16) or a control (C) ( = 15) group.
he intervention was a pedometer program combined with nutrition coaching, with the primary outcome increased weight loss
in the intervention group. Secondary outcomes included decreased waist and hip measurements, improved insulin sensitivity and
body composition, increased physical activity, and improved self-eicacy in eating behaviours. Results. Median (IQR) results were
as follows: weight: I −2.5 (2.3) kg versus C +0.2 (1.6) kg ( = 0.009), waist: I −3.6 (4.5) cm versus C −0.1 (3.6) cm ( = 0.07), and
hip: I −5.0 (3.3) cm versus C −0.2 (2.6) cm ( = 0.002). here was clinical improvement in physical activity and eating behaviours
and no signiicant changes in glucose metabolism or body composition. Conclusion. A pedometer program and nutrition coaching
proved efective in supporting weight loss, waist circumference, physical activity, and eating behaviours in women with previous
GDM.
1. Introduction
Gestational diabetes mellitus (GDM) is a well-established
predictor for the development of type 2 diabetes (T2DM)
[1]. he incidence of GDM has been increasing over the
last iteen years [2], and, with the introduction of updated
clinical guidelines for the diagnosis and management of
GDM, the prevalence in Australia could be as high as 13% [3].
Worldwide, the prevalence of T2DM following GDM may be
as high as 70% [4–9].
In 2007, the economic burden of T2DM was estimated
at approximately $US218 billion [10]. he global burden of
T2DM is immense [11] with one potential solution being
a targeted delay or prevention of progression to T2DM in
high risk populations [12–15]. However, programs designed
to target women following GDM have met with varied levels
of success [16]. Lifestyle intervention trials incorporating
dietary modiication and promoting increased physical activ-
ity to support weight loss have been successful in preventing
T2DM [16–19], demonstrating a reduced risk of progression
to T2DM in high risk groups by up to 58% [20, 21], with a
continuing inluence up to eight years ater the intervention
[22].
In a secondary analysis of the US Diabetes Prevention
Program study, women with documented prior GDM had a
71% greater chance of progressing to T2DM three years later, a
Hindawi Publishing Corporation
International Journal of Endocrinology
Volume 2015, Article ID 423717, 8 pages
http://dx.doi.org/10.1155/2015/423717