Clinical Vignette Association of Intermediate Osteopetrosis with Poikiloderma S. MIGLIACCIO, 1,2 M. LUCIANI, 3 A. TARANTA, 1 G. DE ROSSI, 3 S. MINISOLA, 4 M. EL HACHEM, 5 C. BOSMAN, 6 L. DE FELICE, 7 R. BOLDRINI, 8 A. CORSI, 9 P. BIANCO, 9 and A. TETI 9 A 10-YEAR-OLD FEMALE patient was diagnosed radio- logically with osteopetrosis at the age of 2 months. The patient is the second child of apparently healthy non- consanguineous parents. Her 12-year-old brother was un- affected. The father’s history was negative. The mother’s history revealed the presence of two first grade cousins with Wilson’s syndrome, and the only brother died from sudden infant death syndrome during sleep at the age of 12 months. FIG. 1. 1 Department of Histology and Medical Embryology, University “La Sapienza,” Rome, Italy. 2 Department of Medical Physiopathology, University “La Sapienza,” Rome, Italy. 3 Division of Haematology, Bambino Gesu ` Hospital, Rome, Italy. 4 II Clinica Medica, University “La Sapienza,” Rome, Italy. 5 Dermatologic Unit, Bambino Gesu ` Hospital, Rome, Italy. 6 Department of Experimental Medicine, University “La Sapienza,” Rome, Italy. 7 Cellular Biotechnology Haematology, University “La Sapienza,” Rome, Italy. 8 Division of Pathology, Bambino Gesu ` Hospital, Rome, Italy. 9 Department of Experimental Medicine, University of L’Aquila, L’Aquila, Italy. JOURNAL OF BONE AND MINERAL RESEARCH Volume 14, Number 5, 1999 Blackwell Science, Inc. © 1999 American Society for Bone and Mineral Research 834