The Basal Promoters for the Human Reduced Folate Carrier Gene Are Regulated by a GC-box and a CRE/AP-1-like Element: Basis For Tissue-Specific Gene Expression. ♦ ♦ Johnathan R.Whetstine * and Larry H. Matherly *#ƒ * Department of Pharmacology, and the # Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan. Running Title: hRFC Basal Promoter Regulation Keywords: reduced folate carrier, cell-specific, tissue-specific, Sp1, Sp3, Creb-1, ATF-1, bZip, cJun, basal promoter, transcription Address Correspondence to: Larry H. Matherly, Ph.D. Experimental and Clinical Therapeutics Program Karmanos Cancer Institute 110 E. Warren Ave., Detroit, MI 48201 Tel.: 313-833-0715 (Ext. 2407) Fax: 313-832-7294 E-mail: matherly@kci.wayne.edu Copyright 2000 by The American Society for Biochemistry and Molecular Biology, Inc. JBC Papers in Press. Published on November 14, 2000 as Manuscript M008074200 by guest on February 6, 2016 http://www.jbc.org/ Downloaded from