Revised Version: 5 November 2004 For: J. Biol. Chem. MS# M4:05364 File: PF4/IL8 Heterodimers PF4 and IL8 CXC-Chemokine Heterodimer Formation Modulates Function at the Quaternary Structural Level Irina V. Nesmelova, $ Yuk Sham, ** Arkadiusz Z. Dudek, * Loes I. van Eijk § , Guoping Wu, % Arne Slungaard, * Frank Mortari, % Arjan W. Griffioen, § Kevin H. Mayo $ $ Department of Biochemistry, Molecular Biology & Biophysics and ** the Supercomputing Institute, and * Department of Medicine, Division of Hematology, Oncology & Transplantation and The Stem Cell Institute, University of Minnesota, Minneapolis MN 55455; and § Angiogenesis Laboratory, Departments of Pathology and Internal Medicine, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands; and % R&D Systems Inc., Minneapolis, MN 55413. 1 JBC Papers in Press. Published on November 5, 2004 as Manuscript M405364200 Copyright 2004 by The American Society for Biochemistry and Molecular Biology, Inc. by guest on February 6, 2016 http://www.jbc.org/ Downloaded from