Mutation Research 550 (2004) 145–181 Conference report Meeting Report: EU–US Workshop on Molecular Signatures of DNA damage-induced Stress Responses Cortona, Italy, 26–30 September 2003  Miriam Sander a , Christian Desaintes b , Richard Pelroy c , Wouter Ferro d , Bennett Van Houten e,∗ , Sally Amundson f , Alan Lehmann g , Leon Mullenders h , Susanna-Assunta Sansone i , Peter Stambrook j , Bert van Zeeland h , Harry Vrieling h , Anders Wennborg k a Page One Editorial Services, 403 Carolina Circle, Durham, NC 27707-2252, USA b European Commission DG Research, Brussels 1049, Belgium c NCI/NIH 6130 Executive Blvd., Room 5026 Rockville, Maryland 20850, USA d LUMC—Deptartment of Toxicogenetics, P.O. Box 9503, Leiden 2300 RA, The Netherlands e NIEHS/NIH, 79 Alexander Drive, MD EC-28, Research Triangle Park, NC 27709, USA f NCI/NIH 37 Convent Dr. Bethesda, MD 20892, USA g University of Sussex, Genome Damage and Stability Centre, Falmer, Brighton BN1 9RQ, UK h LUMC—Department of Toxicogenetics, Wassenaarseweg 72, Leiden 2333AL, The Netherlands i EMBL EBI—The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK j University of Cincinnati Medical Center, Vontz Center, 3125 Eden Avenue, Cincinnati, OH 45267-0521, USA k Department of Biosciences, Karolinska Institutet, Novum, Huddinge SE-141 57, Sweden Received 9 February 2004; accepted 12 February 2004 1. Introduction The EU–US Workshop on Molecular Signatures of DNA Damage-induced Stress Responses was held in Cortona, Italy, 26–30 September 2003 and was at- tended by approximately 100 researchers and repre- sentatives of health advisory bodies from the EU and  The EU–US Workshop on Molecular Signatures of Stress-Induced DNA Damage Responses was sponsored by the National Cancer Institute, United States National Institutes of Health, The National Institute of Environmental Health Sciences, and The Directorate General Research of The European Com- mission. Additional information on the meeting is available at http://www.medgencentre.nl/molsign-workshop/CortonaSept2003. htm. ∗ Corresponding author. Tel.: +1-919-541-7752; fax: +1-919-541-7593. E-mail address: vanhout1@niehs.nih.gog (B. Van Houten). US. The workshop was organized jointly by The Na- tional Cancer Institute (NCI, US), The National Insti- tute of Environmental Health Sciences (NIEHS, NIH, US) and The Directorate General Research from the European Commission (EURATOM programme on radiation protection). Three opening keynote lectures provided state-of-art overviews of research on global approaches to study- ing the response to DNA damage, structural biology of DNA repair and DNA replication machines, and the use of bioinformatics in computational systems biology. Four workshop sessions covered key aspects of current research in gene expression profiling, gene discovery and gene regulatory networks, proteomics and the integration of stress response pathways and harmonization of experimental settings and data man- agement. 0027-5107/$ – see front matter doi:10.1016/j.mrfmmm.2004.02.009