Mechanisms by which a CACNA1H mutation found in epilepsy patients increase seizure susceptibility Veit-Simon Eckle 1,2,# , Aleksandr Shcheglovitov 1,3,# , IuliiaVitko 1,# , Deblina Dey 1,4 , Chan Choo Yap 5 , Bettina Winckler 4,5 , and Edward Perez-Reyes 1,5 Departments of 1 Pharmacology and 4 Neuroscience, and the 5 Neuroscience Graduate Program University of Virginia School of Medicine, Charlottesville, VA, USA. 2 Present address: Department of Anesthesiology & Intensive Care, Eberhard-Karls- University,Tübingen, Germany 3 Present address: Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA. # V.-S.E., A.S. and I.V. are co-first authors and contributed equally to the manuscript Corresponding author: E. Perez-Reyes, Jordan Hall 800735, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA. Email: eperez@virginia.edu Running Title: T-type channels in seizure susceptibility Key Words: Epilepsy, T-type channel, CACNA1H, Ca v 3.2, hippocampus, childhood absence epilepsy, gene expression Word Count: 6600 Subject Area: Neuroscience ) at Stanford University Libraries on November 29, 2013 jp.physoc.org Downloaded from J Physiol (