Beilstein-Institut Integration and Annotation of Kinetic Data of Biochemical Reactions in SABIO-RK Ulrike Wittig * , Renate Kania, Martin Golebiewski, Olga Krebs, Saqib Mir, Andreas Weidemann, Henriette Engelken and Isabel Rojas Scientific Databases and Visualization Group, EML Research gGmbH, Heidelberg, Germany E-Mail: * ulrike.wittig@eml-r.villa-bosch.de Received: 30 th April 2008 / Published: 20 th August 2008 Abstract SABIO-RK is a curated database for the systems biology community containing biochemical reactions and their kinetic properties, the latter being manually extracted from literature sources. This information is crucial for the quantitative understanding of biological systems. Mod- ellers and wet-lab scientists alike require reliable information about reaction kinetics which is normally contained in publications generated worldwide. In SABIO-RK kinetic data are related to reactions, organ- isms and biological locations. The type of kinetic mechanism and corresponding rate equations are presented together with their para- meters and experimental conditions. In order to enable comprehensive understanding, integration and comparison of data it is necessary to provide annotations and links to community resources, such as external databases and ontologies that augment the content and the semantics of the SABIO-RK database entries. In this short paper we will present SABIO-RK ( http://sabio.villa-bosch.de/SABIORK) and our approach towards integration and annotation of the kinetic data and their respec- tive biochemical context. 85 http://www.beilstein-institut.de/escec2007/proceedings/Wittig/Wittig.pdf ESCEC, September 23 rd – 26 th , 2007, Ru ¨ desheim/Rhein, Germany