1 © The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity Elena V. Nikonova 1,7,† , Yulan Xiong 2,3,†, Keith Q. Tanis 1 , Valina L. Dawson 2,3,4,5 , Robert L. Vogel 6 , Eva M. Finney 1 , David J. Stone 1 , Ian J. Reynolds 6 , Jonathan T. Kern 6 , Ted M. Dawson 2,3,5, * 1 Exploratory and Translational Sciences, Merck Research Laboratories, West Point, PA 19486, USA; 2 NeuroRegeneration and Stem Cell Programs, Institute for Cell Engineering, Departments of 3 Neurology, 4 Physiology, 5 Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; 6 Neurology, Merck Research Laboratories, West Point, PA 19486, USA; 7 Present address: Department of Computational and Systems Biology, The Wistar Institute, Philadelphia, PA 19104, USA † E.V.N. and † Y.X. contributed equally to this work. *To whom correspondence should be addressed: Ted M. Dawson E-mail: tdawson@jhmi.edu Tel: +1-410-614-3359 Fax: +1-410-614-9568 HMG Advance Access published October 4, 2011 by guest on February 8, 2016 http://hmg.oxfordjournals.org/ Downloaded from