DOI: 10.1126/science.1222939 , 68 (2012); 338 Science Ronald S. Duman and George K. Aghajanian Synaptic Dysfunction in Depression: Potential Therapeutic Targets This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): November 12, 2012 www.sciencemag.org (this information is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/338/6103/68.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/338/6103/68.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/338/6103/68.full.html#ref-list-1 , 13 of which can be accessed free: cites 55 articles This article registered trademark of AAAS. is a Science 2012 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on November 12, 2012 www.sciencemag.org Downloaded from