Chromosome Workshop: Chromosomes 11, 14, and 15 Chair: Nick Craddock*; Co-Chair: Corinne Lendon Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, U.K. Participants: Sven Cichon (Institute of Human Genetics, University of Bonn, Germany) Rob Culverhouse (Department of Psychiatry, Washington University, St. Louis, Missouri) Sevilla Detera-Wadleigh (National Institute of Mental Health, Bethesda, Maryland) Rebecca Devon (MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K.) Steve Faraone (Department of Psychiatry, Harvard Medical School, Boston, Massachusetts) Tatiana Foroud (Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana) Pablo Gejman (National Institute of Mental Health) Sherry Leonard (Department of Psychiatry, University Colorado Health Sciences Center, Boulder, Colorado) Melvin McInnis (Johns Hopkins University, Baltimore, Maryland) Michael J. Owen (Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, U.K.) Brien Riley (Department of Psychological Medicine, Institute of Psychiatry) Contributors: Chris Armstrong (Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri) Nick Barden (Department of Neuroscience, Laval University Research Center) Christine van Broeckhoven (Department of Biochemistry, University of Antwerp, Belgium) Henrik Ewald (Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Denmark) Susan Folstein (Tufts University School of Medicine, Boston, Massachusetts) Daniela Gerhard (Department of Genetics, Washington University School of Medicine, St. Louis, Missouri) David Goldman (NIAAA, Potomac, Maryland) Hugh Gurling (Department of Psychiatry, University College & Middlesex School of Medicine) John Kelsoe (Department of Psychiatry, University California, San Diego, California) Doug Levinson (Department of Psychiatry, Allegheny University Health Sciences, Philadelphia, Pennsylvania) Walter Muir (MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K.) Ann Philippe (INSERM, Paris, France) Ann Pulver (Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland) Dieter Wildenauer (Molecular Genetics Laboratory, University of Bonn, Germany) This report describes linkage data presented at the Workshop on Chromosomes 11, 14, and 15 at the Sixth World Congress of Psychiatric Genetics in Bonn, Germany, together with relevant linkage data submitted to the chair and co-chair, and it is presented in the con- text of the previous literature concerning these chromosomes. We have attempted to collate current linkage data to provide a guide to potentially interesting findings on chromosomes 11, 14, and 15 for the pheno- types of bipolar disorder, schizophrenia, alco- holism, autism, and spelling and reading dis- ability. We discuss methodological limita- tions and provide chromosome ideograms and tables summarizing findings to date. The most promising region currently appears to be 15q13-q15 in the region of the alpha 7 nico- tinic receptor for the phenotype of schizo- phrenia (and, perhaps, more generally for functional psychosis). Additionally, 15q11-q13 in the region of GABRB3 holds interest as a potential site of a susceptibility gene for au- tism. Two regions on chromosome 11, 11p15 in the region of tyrosine hydroxylase gene and 11q22-q23 in the region of DRD2, con- tinue to retain some interest for functional psychosis. Am. J. Med. Genet. (Neuropsychi- atr. Genet.) 88:244–254, 1999. © 1999 Wiley-Liss, Inc. *Correspondence to: Nick Craddock, Division of Neuroscience, University of Birmingham, Queen Elizabeth Psychiatric Hospi- tal, Mindelsohn Way, Birmingham B15 2QZ U.K. E-mail: n.craddock@bham.ac.uk American Journal of Medical Genetics (Neuropsychiatric Genetics) 88:244–254 (1999) © 1999 Wiley-Liss, Inc.