Hindawi Publishing Corporation AIDS Research and Treatment Volume 2013, Article ID 585143, 11 pages http://dx.doi.org/10.1155/2013/585143 Clinical Study Preliminary Evidence for Feasibility, Use, and Acceptability of Individualized Texting for Adherence Building for Antiretroviral Adherence and Substance Use Assessment among HIV-Infected Methamphetamine Users David J. Moore, 1,2 Jessica L. Montoya, 2,3 Kaitlin Blackstone, 2,3 Alexandra Rooney, 1,2 Ben Gouaux, 1,2 Shereen Georges, 1,2 Colin A. Depp, 1,4 J. Hampton Atkinson, 1,2,4 and The TMARC Group 1,2 1 Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA 2 HIV Neurobehavioral Research Program, 220 Dickinson Street, Suite B (8231), San Diego, CA 92103, USA 3 San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120, USA 4 VA, San Diego Healthcare System, San Diego, CA 92161, USA Correspondence should be addressed to David J. Moore; djmoore@ucsd.edu Received 29 March 2013; Revised 21 June 2013; Accepted 26 June 2013 Academic Editor: Seth Himmelhoch Copyright © 2013 David J. Moore et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. he feasibility, use, and acceptability of text messages to track methamphetamine use and promote antiretroviral treatment (ART) adherence among HIV-infected methamphetamine users was examined. From an ongoing randomized controlled trial, 30-day text response rates of participants assigned to the intervention (individualized texting for adherence building (iTAB), n = 20) were compared to those in the active comparison condition (n = 9). Both groups received daily texts assessing methamphetamine use, and the iTAB group additionally received personalized daily ART adherence reminder texts. Response rate for methamphetamine use texts was 72.9% with methamphetamine use endorsed 14.7% of the time. Text-derived methamphetamine use data was correlated with data from a structured substance use interview covering the same time period ( < 0.05). he iTAB group responded to 69.0% of adherence reminder texts; among those responses, 81.8% endorsed taking ART medication. Standardized feedback questionnaire responses indicated little diiculty with the texts, satisfaction with the study, and beliefs that future text-based interventions would be helpful. Moreover, most participants believed the intervention reduced methamphetamine use and improved adherence. Qualitative feedback regarding the intervention was positive. Future studies will reine and improve iTAB for optimal acceptability and eicacy. his trial is registered with ClinicalTrials.gov NCT01317277. 1. Introduction Mobile health (mHealth) interventions aiming to enhance health behaviors have recently proliferated [1]. mHealth strategies are designed to be integrated into the everyday lives of patients in order to minimize barriers to intervention implementation and facilitate use and generalizability [2]. Both the mobility and popularity of cell phones make it possible to remotely deliver services to assist people with behavior modiication and disease self-management [3], thereby improving health outcomes. Short-message service (SMS; i.e., text messaging), in particular, represents a low- cost route to promoting health behaviors, such as treatment adherence, due to the ubiquitous nature of this technology