Applied Mathematical Sciences, Vol. 6, 2012, no. 118, 5877 - 5900 Spread of Antimalarial Drug Resistance in a Population with Superinfection Gasper G. Mwanga Department of Mathematics and Physics Lappeenranta University of Technology Box 20, FIN-53851, Lappeenranta, Finland mwanga.gasper@gmail.com Heikki Haario Department of Mathematics and Physics Lappeenranta University of Technology, Box 20, FIN-53851, Lappeenranta, Finland Betty K. Nannyonga Department of Mathematics, Makerere University Box 7062, Kampala, Uganda Abstract Spread of antimalarial drug resistance and superinfection poses a serious threat in the efficacy of most available antimalarial drugs. In this paper, a deterministic mathematical model for the spread of drug resistance malaria in human population is presented. A new way of mod- eling the superinfection is given by describing primary and secondary stages of malaria infection. The model also enables us to study the role of iron supplementation in superinfection. The effect of prolonging the primary infectious period and supplementation of iron in malaria superinfection and acquisition of temporal immunity are investigated. Numerical simulation results show that the duration of individuals in the primary infectious stage and iron supplements have no effect on the acquisition of immunity. Increasing the duration of primary infection period increases the risk of superinfection, and also effects the pattern of dominant parasite strains over different levels of transmission intensity. The model further shows that increasing the rate of iron supplemen- tation increases superinfection with increase in transmission intensity. This finding has negative implications on the efficacy of antimalarial