1 © The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com Calpain mediated ataxin-3 cleavage in the molecular pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3) Jeannette Hübener 1,#,* , Jonasz Jeremiasz Weber 1,# , Claudia Richter 1 , Lisa Honold 1 , Andreas Weiss 2 , Fabronia Murad 1 , Peter Breuer 3 , Ullrich Wüllner 3 , Peter Bellstedt 1 , Francois Paquet-Durand 4 , Jiro Takano 5 , Takaomi C Saido 5 , Olaf Riess 1 , Huu Phuc Nguyen 1 1 Department of Medical Genetics, University of Tuebingen, 72076 Tuebingen, Germany 2 Neuroscience Discovery, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland 3 Department of Neurology, University of Bonn, 53127 Bonn, Germany 4 Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, 72076 Tuebingen, Germany 5 RIKEN Brain Science Institute, Laboratory for Proteolytic Neuroscience, 351-0198 Saitama, Japan * Address for correspondence: Jeannette Hübener, PhD, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany, Phone: +49-7071-2972276, Fax: +49-7071-295171, Email: jeannette.huebener@med.uni- tuebingen.de # These authors contributed equally to this work. HMG Advance Access published October 24, 2012 at Institut fur MolekulareBiotechnologie e.V. Zweigbibliothek Beutenberg on October 27, 2012 http://hmg.oxfordjournals.org/ Downloaded from