1 Proteomic study of neuron and astrocyte cultures from senescence-accelerated mouse SAMP8 reveals degenerative changes Cristina Díez-Vives 1 , Marina Gay 2 , Silvia García-Matas 1 , Francesc Comellas 3 , Montserrat Carrascal 2 , Joaquín Abian 2 , Arantxa Ortega 4 , Rosa Cristòfol 1 , Coral Sanfeliu 1 1 Department of Brain Ischemia and Neurodegeneration, Institut d’Investigacions Biomèdiques de Barcelona (IIBB), CSIC-IDIBAPS, Barcelona, Spain. 2 CSIC-UAB Proteomics Laboratory Facilities, Barcelona, Spain. 3 Department of Applied Mathematics IV, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain. 4 Department of Pathology, University Hospital Vall d’Hebron (HUVH), Barcelona, Spain. Corresponding author: Coral Sanfeliu, PhD Department of Brain Ischemia and Neurodegeneration Institut d’Investigacions Biomèdiques de Barcelona (IIBB) CSIC-IDIBAPS Rosselló 161, 6 th floor, 08036 Barcelona, Spain. E-mail: coral.sanfeliu@iibb.csic.es Phone: (+34) 933638338 Fax: (+34) 933638301 Abbreviations: AD, Alzheimer’s disease; Aldh2, aldehyde dehydrogenase mitochondrial; CHAPS, 3-[(3-cholamidopropyl) dimethylammonio] propanesulfonate; Cox, cytochrome oxidase; DMEM, Dulbecco’s Modified Eagle’s Medium; FBS, fetal bovine serum; HPI, human protein interactome network; MALDI-TOF-MS, matrix-assisted laser desorption/ionization-time of flight-mass spectrometry; MOWSE, molecular weight search; PBS, phosphate buffered saline; PMF, peptide mass fingerprint; PP1, serine/threonine-protein phosphatase type 1; Ppp1ca, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; SAMP8, senescence-accelerated prone mouse strain 8; SAMR1, senescence-accelerated resistant mouse strain 1; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SUMO, small ubiquitin-like modifier.