©SRDE Group, All Rights Reserved. Int. J. Res. Dev. Pharm. L. Sci. 1070 International Journal of Research and Development in Pharmacy and Life Sciences Available online at http//www.ijrdpl.com June - July, 2014, Vol. 3, No.4, pp 1070-1073 ISSN: 2278-0238 Research Article RELATIONSHIP OF HS-CRP LEVEL IN DIABETIC PERSONS FREE FROM MICRO AND MACROVASCULAR DISEASE Geetha Bhaktha 1 , Manjula Shantaram 2 , Shivananda Nayak 1 , Nagendra S 3 1. Department of Biochemistry, Subbaiah Institute of Medical Sciences and Research Centre, Shimoga, Karnataka, India 2. Department of Biochemistry, PG Centre, ChikkaAluvara, Thorenuur Post, Somwarpet Taluk, Kodagu, Karnataka, India 3. Department of General Medicine, Subbaiah Institute of Medical Sciences and Research Centre, Shimoga, Karnataka, India *Corresponding Author: Email bhakthageetha@rediffmail.com (Received: April 05, 2014; Accepted: May 13, 2014) ABSTRACT C-reactive protein is considered as one of the most sensitive markers of systemic inflammation. Studies have found that increase in the levels of C- reactive protein is associated with the vascular complications. Hence we aimed in finding the correlation of hs-crp with other risk factors like BMI, FBS and HbA1c in diabetic subjects who have still not developed any micro and macrovascular complications. 229 cases of type 2 diabetics and 205 healthy individuals were selected as per the criteria. BMI was calculated, FBS was estimated by glucose-oxidase peroxidase method. Hs-crp was estimated by immunoturbidometric technique. The group was divided into low risk and high risk group as per their hs-crp level. Correlation was seen with other factors like BMI, FBS and HbA1c. The level of Hs-crp was high in diabetic subjects when compared to normal individuals. Further when the diabetic subjects were divided into high risk and low risk groups, the difference between the groups were statistically significant. Hs-crp failed to show any correlation with BMI, FBS and HbA1c. Diabetes is considered as an inflammatory disease hence we observed an increase in the hs-crp level in diabetes than in the normal. Since the vascular complication was totally absent hs-crp failed to show any correlation with BMI, FBS and HbA1c. Keywords: BMI, Diabetic, Hs-crp, vascular complication. INTRODUCTION Diabetes is a metabolic disorder associated with Insulin resistance or insulin action resulting in hyperglycemia. It is considered that hyperglycemia is itself an inflammatory condition. Further classical risk factors like obesity, smoking, hyperlipedemia also exacerbated the condition of inflammation. However inflammatory process is difficult to measure directly. Use of imaging technique or arterial biopsy is not practical. Hence inflammatory biomarkers proved useful information on the inflammatory process. This is a non specific process, any inflammation in other tissue, organs raises the levels of inflammatory biomarkers in the plasma and is associated with the degree of inflammation. Thus a high sensitive method to detect even small variations of these biomarkers in the blood was of choice. Among the several markers of inflammation Hs-CRP is significantly associated with diabetic population. CRP belongs to the pentraxin family and is an acute-phase reactant. It is mostly