115 Copyright © 2016, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. Chapter 7 DOI: 10.4018/978-1-4666-9740-9.ch007 ABSTRACT Virtual Reality is one of the most promising tools in the development of new methods for neuropsychological assessment and rehabilitation. Neuropsychological assessment is typically carried out by administering paper-and-pencil tests to patients. However, these tests have some limitations, due to the fact that they are not efectively able to evaluate the subject’s performance of daily activities. To cope with this void, neuropsychologists base their evaluation on their clinical experience, often successfully. Nevertheless, this is not an evidence-based practice, thus it is not considered optimal from a medical decision-making perspective. More recently, however, the increasing accessibility of advanced technology such as virtual reality has opened new possibilities for neuropsychological assessment and rehabilitation. Starting with this frame, the chapter explores the changes that have occurred over time in the neuropsychological assessment and rehabilitation up to the most recent VR-based tools. In particular, we will present a VR- based PC tool for the assessment of executive functions, and a VR-based mobile tool for the assessment and rehabilitation of unilateral spatial neglect. In accordance with the literature, we show the potential for virtual reality, highlighting the advantages, limitations, and the possible future challenges. The Use of Virtual Reality Tools for the Assessment of Executive Functions and Unilateral Spatial Neglect Elisa Pedroli Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy Silvia Serino Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy Alice Chicchi Giglioli Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy Federica Pallavicini Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy Pietro Cipresso Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy Giuseppe Riva Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Italy & Catholic University of Milan, Italy