Running title: PDGFrα function and sulfatides 1 Dysfunction of PDGFRα represses the production of oligodendrocytes from arylsulfatase A deficient multipotential neural precursor cells Katarzyna C. Pituch a , Ana L. Moyano a , Aurora Lopez-Rosas a , Felecia M. Marottoli a , Guannan Li b , Chenqi Hu b , Richard van Breemen. b , Jan E. Månsson c and Maria I. Givogri a,1 Keywords: glycolipids, lysosomal storage disease, Arylsulfatase A, neural precursor cells, sulfatides, detergent resistant membranes, PDGFrαα, AKT phosphorylation, oligodendrocytes, glia, exosomes. a Department of Anatomy and Cell Biology, College of Medicine. b Department of Medical Chemistry and Pharmacognosy, College of Pharmacy. University of Illinois at Chicago.c Department of Clinical Chemistry. The Sahlgren Academy. University of Gothenburg. Sweden. 1 Author correspondence: Dr. Maria Irene Givogri. Department of Anatomy & Cell Biology, College of Medicine, University of Illinois at Chicago. 808 S. Wood St. M/C 512. Chicago. IL. USA. Telephone 312-413-1072. e-mail: mgivogri@uic.edu. http://www.jbc.org/cgi/doi/10.1074/jbc.M115.636498 The latest version is at JBC Papers in Press. Published on January 20, 2015 as Manuscript M115.636498 Copyright 2015 by The American Society for Biochemistry and Molecular Biology, Inc. by guest on February 26, 2016 http://www.jbc.org/ Downloaded from