ORIGINAL ARTICLE Living Donor and Deceased Donor Liver Transplantation for Autoimmune and Cholestatic Liver Diseases—An Analysis of the UNOS Database Randeep Kashyap & Saman Safadjou & Rui Chen & Parvez Mantry & Rajeev Sharma & Vrishali Patil & Manoj Maloo & Charlotte Ryan & Carlos Marroquin & Christopher Barry & Gopal Ramaraju & Benedict Maliakkal & Mark Orloff Received: 22 February 2010 / Accepted: 7 June 2010 # 2010 The Society for Surgery of the Alimentary Tract Abstract Introduction Autoimmune hepatitis and cholestatic liver diseases have more favorable outcomes after liver transplantation as compared to viral hepatitis and alcoholic liver diseases. However, there are only few reports comparing outcomes of both living donor liver transplants (LDLT) and deceased donor liver transplants (DDLT) for these conditions. Aim We aim to study the survival outcomes of patients undergoing LT for autoimmune and cholestatic diseases and to identify possible risk factors influencing survival. Survival outcomes for LDLT vs. DDLT are also to be compared for these diseases. Patients and Methods A retrospective analysis of the UNOS database for patients transplanted between February 2002 until October 2006 for AIH, PSC, and PBC was performed. Survival outcomes for LDLT and DDLT patients were analyzed and factors influencing survival were identified. Results Among all recipients the estimated patient survival at 1, 3, and 5 years for LDLT was 95.5%, 93.6%,and 92.5% and for DDLT was 90.9%, 86.5%, and 84.9%, respectively (p =0.002). The estimated graft survival at 1, 3, and 5 years for LDLT was 87.9%, 85.4%, and 84.3% and for DDLT 85.9%, 80.3%, and 78.6%, respectively (p =0.123). On multivariate proportional hazard regression analysis after adjusting for age and MELD score, the effect of donor type was not found to be significant. Conclusion The overall survival outcomes of LDLT were similar to DDLT in our patients with autoimmune and cholestatic liver diseases. It appears from our study that after adjusting for age and MELD score donor type does not significantly affect the outcome. This paper was presented as an oral presentation at ATC meeting 2008 Toronto, Canada. Randeep Kashyap participated in research design, writing of the paper, and data analysis. Saman Safadjou participated in research design and data analysis. Rui Chen, Rajeev Sharma, and Vrishali Patil participated in data analysis. Parvez Mantry, Manoj Maloo, Gopal Ramaraju and Benedict Maliakkal participated in research design. Charlotte Ryan participated in the writing of the paper. Carlos Marroquin and Christopher Barry participated in the performance of the research. Mark Orloff participated in research design, writing of the paper, and performance of the research. R. Kashyap (*) : S. Safadjou : R. Sharma : V. Patil : C. Marroquin : C. Barry : M. Orloff Department of Surgery, Division of Solid Organ Transplantation, University of Rochester Medical Center, P.O. Box SURG, 601 Elmwood Avenue, Rochester, NY 14642, USA e-mail: randeep_kashyap@urmc.rochester.edu R. Chen Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA P. Mantry Liver Institute, Methodist Dallas Medical Center, Dallas, TX, USA M. Maloo Department of Surgery, Geisinger Health System, Danville, PA, USA J Gastrointest Surg DOI 10.1007/s11605-010-1256-1