DIABETES Abstracts 53 – 61 Moderators: Alan Tita, MD; Tom Moore, MD 53 The distribution of fetal cardiac structural malformations in women with and without diabetes mellitus Luissa Kiprono 1 , Lynda Robinette 1 , James Bofill 1 1 University of Mississippi Medical Center, Maternal-Fetal Medicine, Jackson, MS OBJECTIVE: To compare the distribution of prenatally-diagnosed fetal cardiac malformations (FCM) in women with pre-gestational diabe- tes mellitus (DM) compared to those women whose FCM was not associated with diabetes. STUDY DESIGN: Retrospective study from a single tertiary care center. Targeted ultrasound and fetal echocardiography was performed by ma- ternal-fetal medicine fellows and faculty. Ultrasound reports containing the diagnosis of FCM were identified and medical records reviewed. Cases where FCM was associated with aneuploidy or other chromosomal aberrations were excluded. Each case of FCM was placed into one of 5 Classes depending on the pathogenetic mechanism of malformation as follows: Class I, Tissue Migration Abnormalities; Class II, Abnormal In- tracardiac Blood Flow; Class III, Cell Death Abnormalities; Class IV, Ex- tracellular Matrix Abnormalities; and Class V, Looping and Situs Defects. Statistics included Pearson chi2, Fisher’s Exact, and one-way ANOVA, a P value ⬍ .05 was considered significant. RESULTS: From January 2002–December 2011 there were 147 patients with prenatal diagnosis of FCM. Of these, 25 (17%) had DM and 122 (83%) did not. Mean maternal age did not significantly differ between the groups (DM 26.0y ⫹ 6.1; No DM 25.1y ⫹ 6.2; p .486). The racial composition of the groups was also similar (DM 55% AA; No DM 66% AA; p .229). There was statistically significant difference between the groups for Class I, II, and IV FCM (Table). CONCLUSION: There are statistically significant differences in the dis- tribution of FCM between patients who have DM and those who do not.With regard to FCM, fuel-mediated teratogenesis produces an overabundance of lesionsfrom Tissue-Migration abnormalities (Class I) and Extracellular-matrix abnormalities (Class IV) while pro- ducing fewer cases where Abnormal Intracardiac blood flow (Class II) is the causative factor. 54 The influence of a low glycaemic index dietary intervention on maternal glycaemic index, dietary gestational weight gain Jennifer Walsh 1 , Ciara McGowan 1 , Jacinta Byrne 1 , Michael Foley 1 , Rhona Mahony 1 , Fionnuala McAuliffe 1 1 National Maternity Hospital, University College Dublin, Dublin, Ireland OBJECTIVE: The aims were to evaluate the effects of a low GI diet intervention on maternal GI, dietary intake and gestational weight gain in pregnancy. STUDY DESIGN: This was a randomised control trial. Healthy secun gravid women who previously delivered a macrosomic infant w included in this study. Participants were randomised to receive dietary advice in early pregnancy or to standard care. A 3-day diary was completed at each trimester. Dietary data were ente WISP and analysed in PASW statistics version 18.0. All particip were weighed and measured in early pregnancy and weight ga monitored at each subsequent antenatal visit. RESULTS: Five hundred and twenty women who returned comple food diaries were included in the present analysis. After the die intervention the number of women in the intervention group w the lowest quartile of GI increased from 37% in the first trimes 52% in the third trimester (p⬍0.001). The intervention group had significantly lower reported energy intake (p⬍0.05), higher pro (%TE) (p⬍0.01) and higher dietary fibre intake (p⬍0.01). Cons tion of high GI foods was significantly reduced among the inter tion group. More women in the control group exceeded the gest tional weight gain goals for pregnancy (45% vs. 33%, p⫽0.009) CONCLUSION: A low GI dietary intervention in early pregnancy had positive influence on maternal GI, food intake and gestational gain.Women at risk of exceeding the gestational weight gain go may benefit from following a low GI diet during pregnancy. 55 Occurrence of pregnancy complications in women with BMI >25 submitted to a healthy lifestyle and eating habits program Elisabetta Petrella 1 , Fabio Facchinetti 1 , Valentina Bertarini 2 , Lucrezia Pignatti 1 , Isabella Neri 1 , Nino Carlo Battistini 2 1 University of Modena and Reggio Emilia, Mother-Infant Department, Modena, Italy, 2 University of Modena and Reggio Emilia, Clinical Diagnost Medicine and Public Health, Modena, Italy OBJECTIVE: We evaluated if changing eating habits and introducin correct lifestyle in women with BMI ⬎25 would improve unfavo maternal-fetal outcomes associated with excessive weight gain in pregnancy. STUDY DESIGN: In a prospective design, women with BMI⬎25 at 1s trimester were randomized to no intervention (28 cases) or a T peutic Lifestyle Changes (TLC) Program including diet (1500 kc day) and mild physical activity (30 minutes/day, 3 times/week) At baseline and at 3rd trimester women filled-in a Food Freque Questionnaire (FFQ). Patients with chronic disorders were exclu Prenatal care was similar in both groups. Outcomes included d ses of GDM (75 g OGTT at 24-28 weeks) or gestational hyperte weight gain, and Preterm Delivery. Data were stratified by BMI RESULTS: Socio-demographic features were similar between grou delivery, women of TLC group (78.9%) remained in IOM recom weight gain ranges significantly more than controls (44%, p⫽0. occurrence of GDM, gestational hypertension and Preterm Deli Distribution of FCM between patients with and without DM DM, diabetes mellitus; FCM, fetal cardiac malformations. Oral Concurrent Session 5 www. AJOG .org Friday, February 15, 2013 • 1:15 pm – 3:30 pm • Continental 1-4 Supplement to JANUARY 2013 American Journal of Obstetrics & Gynecology S33